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Hyper-interleukin-6 allows paralysed mice to walk again
Treating only a few nerve cells with the hyper-interleukin-6 (hIL-6) gene therapy stimulated the regeneration of nerves.
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Drug Delivery
Drug delivery refers to approaches for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect.
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New inhaled therapy could treat deadly impacts of asthma
Scientists have developed an inhaled treatment for asthma that prevents excess mucus from building up in mice.
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Inhaled vaccine induces strong immune response in animal models
Scientists report their phage-based inhaled vaccine delivery system elicited a robust antibody response in both mice and non-human primates.
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CRISPR-based treatment successfully targets glioblastoma and ovarian cancers in vivo
Researchers say this is the first time that CRISPR-Cas9 gene editing has been used to treat cancer effectively in a living animal and that the technique could be revolutionary.
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Novel nanoparticle therapy shows promise in glioblastoma
The synthetic protein nanoparticle can cross the blood-brain barrier and deliver a targeted therapeutic to glioblastoma cells, say researchers.
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Researchers use somatostatin to treat Alzheimer’s in mice
A team fused the peptide somatostatin to a brain transport protein and found it treated memory loss associated with Alzheimer's in mice.
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Novel siRNA therapy improves psoriasis in mice
Topical delivery of a small interfering RNA (siRNA) using an ionic liquid complex significantly reduced levels of inflammatory cytokines and symptoms of psoriasis.
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siRNA nanomedicine shows promise Alzheimer’s treatment in mice
Researchers have shown that an siRNA nanomedicine can target BACE1 in a mouse model of Alzheimer's, restoring cognitive capacity.
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Novel GI tract coating could deliver drugs, aid digestion or control obesity
The developers of a temporary coating which adheres to the small intestine demonstrated it could be modified to deliver drugs, aid digestion and stop absorption of glucose.
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Novel antiplatelet drug is effective at treating heart attacks in mice, say researchers
The novel nanoparticle delivered Mp6 peptide was able to inhibit thrombosis and reduce inflammation without increasing the risk of bleeding in mice after heart attacks.
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Novel biomaterial could be used to accelerate bone regeneration
In lab conditions, a new biomaterial was able to accelerate bone regeneration by boosting an immune response that encourages repair.
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Empty phage viruses as a method to combat influenza
A group of German researchers has proposed an empty phage capsid with ligands on its surface as a novel technique to treat influenza.
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Novel gene promoters could improve gene therapies for neurological diseases
Novel promoters based on those in the herpes viruses, enabled delivery of larger genes and increased the period they were active in the nervous system.
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MERS vaccine candidate could hold promise for COVID-19 vaccine
The vaccine candidate protected all murine models from a lethal MERS infection and could also be effective against the SARS-CoV-2 virus causing COVID-19.
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Novel biocompatible microparticles can be created using heat and light
Scientists have demonstrated an innovative technique for creating microparticles for tissue engineering out of a combination of disordered and partially ordered proteins.
