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Supercoils in DNA could give insights to antibiotic drug development
DNA gyrase, a molecular machine used to prevent DNA from coiling, could be used to ensure bacterial DNA coils, reducing the risk of infection to humans...
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Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Cryoablation could treat low risk breast cancer
A study by Princeton Radiology researchers has found that cryoablation could be effective in targeting low risk breast cancer...
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The role of drug transporters in phenotypic screening
The relative failure of molecular target-based drug discovery has led to a return to phenotypic screening. Targets that are intracellular necessitate their drug ligands to pass through plasma membranes, where the protein:lipid ratio is often 3:1 by mass and at least 1:1 by area. The widespread view that most of…
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Transporting proteins into cells to mitochondria
J-proteins such as Xdj1, as helpers of the heat shock protein 70 chaperones, and were found to be involved in the transport of proteins to the mitochondria...
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Halting the spread of brain cancer
Mouse models used to show how convection enhanced delivery caused glioma cells to invade the rest of the brain could help to prevent this spread in future...
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Study reveals 35 genes linked to chronic kidney disease
A study conducted by researchers at The University of Manchester and Manchester Children's Hospital has revealed 35 genes linked to chronic kidney disease...
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Stopping cancer cells in their tumour ‘highways’
Using controlled network microenvironments, tumour cells were prevented from travelling, which could prevent spread of the cancer throughout the body...
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War On Cancer 2018: targeted therapies in oncology
War On Cancer 2018 discussed how cancer treatments have evolved over the last few decades, and looked at the future of cancer therapies...
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Muscular paralysis progression could be reduced using tamoxifen
Currently used for breast cancer, tamoxifen could be useful in preventing the progression of myotubular myopathy, a severe genetic disease...
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PCSK9 inhibitors to treat high cholesterol
Low-density lipoprotein cholesterol could be treated by using synthetic DNA-encoded monoclonal antibodies to inhibit PCSK9...
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Inhibiting inflammation by blocking release of TNF alpha
Researchers at Karolinska Institutet collaborated with other researchers to develop a compound that prevents inflammation by blocking release of TNF alpha...
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Drug candidate offers hope of vocal improvement for ADNP syndrome
Scientists have uncovered a promising drug candidate that appears to normalise the vocal communication mechanism deficiencies experienced in genetic disorder ADNP.
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Application note: Cellular dopamine and intracellular calcium signaling using the next generation HTS microplate reader
This application note highlights the direct optic bottom reading performance of the BMG LABTECH microplate readers in two different cell-based fluorescence intensity assays from Invitrogen.
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Precision neuroengineering reproduces brain-like functions in vitro
Using precision engineering, researchers form Japan and Spain have collaborated to show brain-like functions in vitro to advance medical research...
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Vaccinia virus hijacks cellular movements to spread
To spread throughout the body, the vaccinia virus mimics the infected cells' own proteins enabling the cell to move around and spread...
