news
Small-molecule cocktail could improve use of stem cells in treatments
Researchers have shown that Chroman 1, Emricasan and trans-ISRIB, in combination with polyamines, are effective at protecting induced pluripotent stem cells from stress.
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High-Throughput Screening (HTS)
webinar
Realise the true power of your online, atline and offline biologics data
22 April 2021 | By IDBS
Register today for our on-demand upcoming webinar and discover more on about Polar High-Throughput Process Development (HTPD).
news
Fragment screening used to identify potential SARS-CoV-2 antivirals
Researchers have used fragment screening alongside computational docking to reveal 20 hit antiviral compounds against SARS-CoV-2.
webinar
Hit discovery for GPCRs: HTS or virtual screens?
8 April 2021 | By Beacon Discovery
Watch our on-demand webinar and learn from an industry expert regarding GPCR virtual screening approaches and challenges and much more.
news
X-ray screening reveals two promising SARS-CoV-2 drug candidates
Using a high-brilliance X-ray lightsource and protein crystallography, researchers have identified two drugs that inhibit the main protease of SARS-CoV-2.
article
Expanding accessible chemical space through automated high-throughput experimentation
Dr Sam Liver, Manager of the High-Throughput Molecular Discovery Laboratory at the Rosalind Franklin Institute, explains how lab automation in the form of machine learning and high‑throughput experimentation (HTE) can be implemented to enhance productivity in autonomous molecular discovery.
article
A novel assay to reveal cyclic peptides with affinity to ubiquitin
Although macrocyclic peptides make for promising pharmaceutical candidates, screening for lead peptides has proved difficult for scientists. In a new study, researchers at the Technion-Israel Institute of Technology addressed these challenges by developing a novel high-throughput screening assay for cyclic peptides with affinity to the ubiquitin protein. Drug Target Review’s…
news
Compounds that inhibit main protease of SARS-CoV-2 discovered
Using high-throughput screening techniques, researchers have identified two families of active substances that block SARS-CoV-2 replication.
news
High-throughput screening market set to be worth $26.4bn by 2025
According to a new report, the high-throughput screening market will increase at a CAGR of 11.5 percent from 2020 to 2025.
news
Behavioural screen in C. elegans reveals Parkinson’s drug candidates
Researchers have developed a workflow to study the behaviour of C. elegans in a high-throughput screen to identify Parkinson's disease drugs.
news
High-throughput screening assay for macrocyclic peptides developed
A high-throughput screening assay for macrocyclic peptides with affinity to ubiquitin has been created by researchers.
whitepaper
Whitepaper: Automated cell culture and screening
This whitepaper describes the automated culturing of hiPSC-derived cells for high-throughput phenotypic screening, using validated phenotypic assays.
webinar
New methods towards efficient and high-throughput drug-target screening
17 December 2020 | By Living Systems Institute, University of Exeter
Watch our on-demand webinar where we explore new methods to improve data quality from high-throughput screens. You'll learn about solutions for common problems in drug-target discovery and our keynote speaker will also look at case studies where new approaches to screening have identified high-quality candidate drugs for proliferative diseases.
article
Antimicrobial resistance – a public health emergency on the horizon
Researchers at Ingenza and the University of Plymouth are using a machine learning and high‑throughput screening approach to discover novel antimicrobial therapies. In this article, Nikki Withers spoke to one of the researchers, Jack Kay, to hear about the current threat posed by antimicrobial resistance and how he hopes their…
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Screening In-Depth Focus 2020
In this in-depth focus find out how genetic screening can be used to customise healthcare and why scientists have turned to machine learning in the fight against antimicrobial resistance.
