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Immunotherapy

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Biomarkers identified that predict immunotherapy success

10 January 2018 | By Drug Target Review

Researchers in Switzerland have identified biomarkers in the blood that can predict which patients are likely to respond favourably to immunotherapy treatment for cancer.

whitepaper

Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology

3 January 2018 | By Daniel Cardillo (PerkinElmer), Dawn Nida (PerkinElmer), Hong Cao (PerkinElmer), Jen Carlstrom (PerkinElmer)

In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.

Discovery of novel targets and therapeutics for Crohn’s disease

news

Faulty gene could be responsible for some Crohn’s disease cases

19 December 2017 | By Steve Bremer (Drug Target Review)

Interaction between MDR1 gene and TH17 immune cells in the ileum could hold the key to Crohn's disease in some instances.

Novel compound restores immune response in patients with melanoma

news

Novel compound restores immune response in patients with melanoma

8 December 2017 | By Drug Target Review

A novel compound may restore immune response in patients with melanoma, according to a study presented at the ESMO Immuno Oncology Congress 2017.1

news

DNA mutations shed in blood predicts response to immunotherapy

2 December 2017 | By Dr Zara Kassam (Drug Target Review)

Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...

webinar

Advancing the discovery of immunotherapeutics with large scale multiplexed experiments

27 September 2017 | By IntelliCyt Corporation

In this webinar, Belen Ybarrondo, Ph.D and Thomas Duensing, Ph.D discuss the challenges faced with antibody screening and how the iQue Screener can give an evaluation of cell killing mechanism, screening for immune checkpoint inhibitors and more...

whitepaper

Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity

25 September 2017 | By IntelliCyt Corporation

In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...

Evaluating immunotherapeutic approaches with large scale functional assays for immuno-oncology

webinar

Evaluating immunotherapeutic approaches with large scale functional assays for immuno-oncology

22 September 2017 | By IntelliCyt Corporation

In this webinar, Belen Ybarrondo, Ph.D and Thomas Duensing, Ph.D discuss the need for robust high content tools for current immunotherapeutic approaches, and how IntelliCyt's iQue Screener PLUS can give functional efficacy of immuno-oncology therapies...

news

Cell surface protein may offer target in treating childhood cancers

12 September 2017 | By Dr Zara Kassam (Drug Target Review)

Immunotherapy drug candidate could be potent weapon against neuroblastoma and other paediatric malignancies...

news

New metabolic target in quest to control immune response

6 September 2017 | By Dr Zara Kassam (Drug Target Review)

Immune cells could help to increase immune activity in vaccines or suppress immune reactions in autoimmune diseases...

news

Immune system can be modulated by targeted manipulation

21 August 2017 | By Dr Zara Kassam (Drug Target Review)

Manipulation of the sugar metabolism and associated modulation of the immune system could open up new options for treating specific infectious and also autoimmune diseases...

news

Novel immunotherapy technology for prostate cancer

18 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have described a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA...

news

Researchers find switch that turns on immune cells tumour-killing ability

17 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researcher have shown how a mRNA molecule known as Lethal-7 serves as a molecular control hub to direct the function of cytotoxic T lymphocytes...

news

Prospects identified for immunotherapy treatments

9 August 2017 | By Dr Zara Kassam (Drug Target Review)

A report published has identified the prospects of immunotherapy treatments...

news

CNIC scientists find the key to improved cancer immunotherapy

18 July 2017 | By Dr Zara Kassam (Drug Target Review)

The study demonstrates that tissue-resident and circulating memory T cells cooperate in anti-tumour immunity...

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Immunotherapy