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Five recent cell and gene therapy discoveries
This article highlights five of the latest findings using cell and gene therapy techniques that could be used in the development or design of new therapies.
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Immunotherapy
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Application note: Droplet Digital polymerase chain reaction (ddPCR) is well suited for quantifying transgene copy number
This application note discusses why CAR T-cell therapy is so exciting, notes some common hurdles in development and manufacturing and proposes ddPCR technology as a solution for some of these issues.
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Product hub: Analyse nearly 100 cytokines using two cytokine panels
Cytokine multiplex assays allow researchers to measure multiple cytokines, chemokines and growth factors from one small sample.
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Nanotechnology: a new immuno-onocology weapon
This article outlines three innovative studies that use nanotechnology to deliver a new immunotherapy approach towards cancers.
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Keeping T cells strong and improving cancer immunotherapy
The tumour microenvironment can prevent some T cells from carrying out their immunotherapeutic duties. In this Q&A, Dr Brian Shy, Clinical Instructor at the University of California, San Francisco (UCSF) Department of Laboratory Medicine, describes a recent study wherein he and fellow scientists discovered a strategy to strengthen T cells…
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Drug Target Review Cell and Gene Therapy Supplement 2022
This supplement focuses on how cell and gene therapy can target diseases such as cancer and reduce elevated lipoprotein(a).
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Immune cells in ALS patients: predicting disease progression
Swedish researchers have discovered that by measuring immune cells in the cerebrospinal fluid when diagnosing ALS, it is possible to predict how fast the disease may progress.
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Novel nanoparticles deliver innovative cancer chemoimmunotherapy
University of Pittsburgh researchers have designed cancer-fighting nanoparticles that co-deliver a chemotherapy drug and a novel immunotherapy
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Novel ‘prodrug’ designed to eliminate cancer without harming healthy cells
US researchers discovered in a study in mice that augmented drug eliminates cancer cells without causing toxicity.
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Bacteria in a tumour’s microbiome could influence how cancer responds to treatment
US researchers find that bacteria could help tumours progress and resist treatment.
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Cancer immunotherapy adapted to treat COVID-19 variants
US researchers have utilised a cancer immunotherapy technique, CAR-T cell method to effectively eliminate SARS-CoV-2 virus pre- and post-infection in vitro.
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Five recent CRISPR drug target discoveries
This article highlights five of the latest findings revealed using CRISPR that could be used in the development or design of new therapies.
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Highlights from PEGS Europe’s Protein & Antibody Engineering Summit
Drug Target Review’s Ria Kakkad recently travelled to Barcelona to attend PEGS Europe’s Protein and Antibody Engineering Summit. In this article, she shares her highlights from the event.
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First use of CRISPR to substitute genes for cancer treatment
US scientists, using CRISPR technology, removed specific genes in humans to allow the immune system to be more activated against cancer.
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Novel CAR T screens identify most effective cancer immunotherapy cells
Researchers have developed a new method for comparing CAR T cells, each with slightly different molecular features, to determine which is most effective and long-lasting against cancer.
