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In Vitro

red viruses pouring out of pink human cell

news

Approved MS medication inhibits SARS-CoV-2 replication in vitro

5 October 2020 | By Hannah Balfour (Drug Target Review)

Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

colourful SARS-CoV-2 particles surrounding a body shape with the lungs drawn in red

news

The NF-κB pathway drives fatal inflammation in COVID-19, say scientists

2 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.

Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].

news

Identifying radioresistance drivers in glioblastoma multiforme

1 October 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, Rab27b and epiregulin contribute to the development of radioresistance and could be targeted to improve glioblastoma patient survival.

SARS-CoV-2 viral particle next to a single RNA strand

news

Novel RNA-targeting molecule can halt SARS-CoV-2 replication

1 October 2020 | By Hannah Balfour (Drug Target Review)

The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.

SARS-CoV-2 particles entering human cells

news

Could a sphingosine nasal spray prevent COVID-19?

30 September 2020 | By Hannah Balfour (Drug Target Review)

According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.

stem cell culture stored in liquid nitrogen

news

Regulating cell plasticity through CDK8 inhibition

29 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers show CDK8 inhibition reduces cell plasticity without damaging cells and suggest their approach could have implications for autoimmunity and oncology.

Agar plate in the hand of a medical technician working on bacterial culture and drug resistance.

news

Novel compounds show efficacy against C. diff

28 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed two novel trifluoromethylthio compounds which showed potent activity in protecting mice from Clostridioides difficile (C. diff) infection.

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

news

Experimental antiviral AR-12 could be a promising COVID-19 treatment

23 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.

cancer cell in red being attacked by a white T cell

article

Developing IL-15 superagonists for cancer therapy

23 September 2020 | By Hannah Balfour (Drug Target Review)

Richard Sachse discusses how immunotherapies targeting interleukin 15 (IL-15) signalling can be optimised to enhance their efficacy and limit off-target effects.

news

Novel pseudo-virion probes to study SARS-CoV-2 viral entry

18 September 2020 | By Hannah Balfour (Drug Target Review)

The non-infectious quantum dot probes are designed to enable researchers to safely study interactions between the SARS-CoV-2 Spike (S) protein and human cells.

news

Could FDA-approved drug heparin prevent SARS-CoV-2 infection?

17 September 2020 | By Hannah Balfour (Drug Target Review)

SARS-CoV-2 entry into human cells is dependent on heparan sulfate and disrupting this interaction using heparin reduces infectivity of the coronavirus, find scientists.

news

Tiny antibody component could treat or prevent SARS-CoV-2

15 September 2020 | By Hannah Balfour (Drug Target Review)

The component, now developed into a drug called Ab8, was highly effective at treating and preventing SARS-CoV-2 infection in animal models.

cancer cell in yellow being attacked by white blobs - cancer drug/cell therapy

news

Study identifies potential therapeutic targets for most lethal pancreatic cancer

15 September 2020 | By Hannah Balfour (Drug Target Review)

The detailed analysis of adenosquamous cancer of the pancreas (ASCP) suggested FGFR and RORC were two promising therapeutic targets.

article

Antibody therapeutics for COVID-19

10 September 2020 | By Dr Janice M Reichert (The Antibody Society)

In 2019, the SARS-CoV-2 coronavirus sparked a global pandemic that is likely to continue into 2021. Effective therapeutics that treat the symptoms of the disease and prevent or treat the underlying viral infection are critically required. To meet this need, the global biopharmaceutical industry is evaluating over 50 monoclonal antibody…

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In Vitro