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“Untreatable” cases of cystic fibrosis may be undermined by new therapy
An experimental drug suggests that therapy for currently untreatable cases of cystic fibrosis is “clearly achievable”.
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In Vivo
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Treg cells could be answer to multiple sclerosis treatments, say scientists
New research has shown that the protein Piezo 1 prevented Treg cells from controlling the effects of inflammation in a multiple sclerosis mouse model.
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Metabolite could defend against harmful intestinal bacteria, study shows
Acetate was found to be involved in regulating complex microbes and could help trigger an immune response against harmful bacteria in mice.
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Non-invasive optical method could provide insight into brain diseases
A non-invasive, label-free optical method can produce high-resolution imaging of cellular brain diseases in vivo.
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High-quality, rapid technique developed for imaging in vivo
A US team has designed a high-quality, high-speed imaging system that could lead to new understandings of complex tissue specimens.
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New spray shown to help heal heart attack damage in rats
A team have developed a minimally invasive exosome spray that helped repair rat hearts after myocardial infarction.
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Metal-based molecule could inhibit build-up of Alzheimer’s peptides
UK researchers have created a metal-based molecule that inhibits the build-up of Alzheimer’s-associated peptide, amyloid-β, in lab tests.
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Prenatal editing halts progression of Hurler syndrome in pre-clinical model
US researchers used an AAV9 vector to edit a single base mutation in a prenatal mouse model, halting progression of Hurler syndrome.
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How engineered RNA binding proteins delivered in vivo by gene therapy could treat myotonic dystrophy
In this article, Dr Jim Burns discusses promising pre-clinical results of how a new platform could treat the root cause of many devastating genetic diseases including myotonic dystrophy type 1.
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Scientists publish guide for creating mouse-human chimeric embryos
Researchers have published a step-by-step protocol on how to produce millions of mature human cells in a chimeric mouse embryo.
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Synthetic antibody treats congenital myasthenia in mice
Researchers have designed an antibody that attaches to MuSK, which prevented early lethality of mice with congenital myasthenia.
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Stem cells used to enhance immune response to HIV in primates
In non-human primates, researchers have found that mesenchymal stem cells were effective at strengthening the immune response to HIV.
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Novel vaccine against coronaviruses protects mice from infection
A new mRNA-based vaccine has demonstrated success at protecting against multiple coronaviruses in pre-clinical studies.
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Dual antibodies effective against SARS-CoV-2 variants in animal study
In mice and hamsters, therapies made from two antibodies were found to be mostly effective against a range of SARS-CoV-2 variants.
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Under the microscope: Exploring phage display technologies for drug discovery and early development
With over 20 years’ of expertise in phage display, IRBM applies its extensive peptide and antibody libraries to discover lead therapeutic candidates. Dr Licia Tomei, Director of Display Technologies, IRBM, discusses the company’s phage display capabilities and how they accelerate the drug discovery process.
