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Mushroom growth method could help develop antivirals and cancer drugs
Although Cordyceps mushrooms are challenging to cultivate, researchers have shown that they can be grown on edible insects to exploit their strong therapeutic potential.
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Medicinal Chemistry
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Cell painting approach used to identify drug compounds with unwanted side effects
Novel research has shown that morphological fingerprinting could help identify side effects of new bioactive compounds in drug discovery.
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Possible new class of compounds to treat diabetes identified
A recent pre-clinical study from Washington University School of Medicine showed that a new class of compounds can potentially improve multiple aspects of metabolic syndrome, including diabetes.
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Virtual method enables screening of billions of chemical compounds
A new platform, named Virtual Synthon Hierarchical Enumeration Screening, has been developed by researchers to efficiently discover drugs.
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Transformational machine learning approach could accelerate drug design
In this Q&A, Professor Ross King from the University of Cambridge, UK, discusses how a new machine learning approach could aid drug discovery and development. The method learns from multiple problems and improves performance while it learns.
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Team identifies lead compound to potentially treat schistosomiasis
Researchers have found a quinoxaline-core containing, non-genotoxic lead compound that could treat schistosomiasis following optimisation.
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Human iPSC-derived cardiomyocytes for cardiac proarrhythmic risk assessment
Following Drug Target Review's webinar supported by Eurofins, speaker Dr Verena Albert answers the questions posed by the audience during the live event.
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Sample preparation automation in label-free compound profiling
Following the latest Drug Target Review webinar, supported by Analytik Jena, we put the audience’s questions to the speakers to understand how hardware, software and labware challenges can be successfully overcome.
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Bioactivity information of one million molecules compiled
Using deep machine learning, researchers have completed the activity profiles, from chemistry to clinical level, for one million molecules.
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Millennia in the making: unlocking the medicinal value of CBD
Dr Sotirios Karathanasis discusses the history of cannabis as a treatment and delves into the process of turning plant-based medicines into clinically proven drugs.
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Automated method to produce synthetic DNA created
Researchers have developed a technique to synthetically produce DNA oligonucleotides that avoids the degradation of phosphoramidites.
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Novel PF74-like small molecules developed to target HIV capsid protein
Scientists have developed PF74-like small molecules able to target the HIV-1 capsid protein, identifying four potent compounds.
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Team modifies therapeutic molecule to improve stroke treatment
Researchers have shown that adding a polymer to glutamate-oxaloacetate transaminase means the molecule can treat stroke for up to six days in rats.
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Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
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BenevolentAI hires new head of Cheminformatics from The Institute of Cancer Research
BenevolentAI announced today it has hired Dr Nathan Brown, as its new Head of Cheminformatics following the promotion of Mark Davies...