article
Exploring future spinal cord injury therapies
Drug Target Review explores five of the latest research developments in the field of spinal cord injury (SCI) repair.
List view / Grid view
Neurons
news
New gene therapy for Huntington’s demonstrates success in mice
Researchers have developed a new regenerative gene therapy using neurogenic differentiation, which has shown efficacy treating Huntington's disease in mice.
article
Could dolphins be viable models for human brain disorders?
Neuropathologic similarities between dolphins and humans suggest that the former could act as an effective model for the study of diseases such as Alzheimer’s. Professor Giovanni Di Guardo explains why dolphins could provide researchers with a new window into neurodegenerative conditons.
news
Receptor protein activity could prevent neuropathy for chemotherapy patients
A team of researchers in Singapore has studied the activity of a receptor protein to identify whether it’s a key player in the development of neuropathy for patients undergoing chemotherapy.
news
Gene found to protect motor neurons against degeneration
Results of an international collaboration show promise for the future of motor neurone disease treatment efforts, as protective gene is identified.
news
YAP protein identified as new target for Alzheimer’s disease
Researchers have discovered that neuronal necrosis occurs in Alzheimer's earlier than previously though and revealed the YAP protein as a potential target.
news
Study identifies brain stiffness as crucial for neurogenesis
A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.
news
Oligodendrocyte abnormality identified as potential cause of autism
Researchers have revealed that the disruption of oligodendrocytes, which produce myelin, may be a cause of autism spectrum disorder, so presents a therapeutic target.
news
C1 compound identified as promising Alzheimer’s drug candidate
Researchers have screened thousands of drugs to discover that C1 effectively blocks the production of amyloid fibrils, so could be an effective therapeutic.
news
Genome screen in mice reveals Huntington’s disease gene target
Researchers have conducted a genetic screen in mice to discover a family of genes that contributes to the development of Huntington's.
news
Diabetes-related proteins examined for the first time at high resolution
A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
news
Pharmacological chaperone therapy shown to prevent Alzheimer’s in mice
A new study is the first to describe a novel pharmacological chaperone that is capable of preventing Alzheimer's disease in mice.
news
Researchers discover how gut infections may produce chronic symptoms
A new study into why neurons in the gut die and how the immune system protects them could lead to better treatments for IBS that work by boosting polyamine production.
news
Researchers discover potential diet drug strategy without feeling of nausea
A study has revealed a brain circuit in mice that suppresses the need to eat without a feeling of nausea, presenting a new strategy for diet drugs.
news
Novel small molecule could treat Alzheimer’s disease and Dravet syndrome
A new experimental drug was shown by researchers to restore natural brain rhythms in mouse models of Alzheimer’s and promote learning and memory.
