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Gene found to protect motor neurons against degeneration
Results of an international collaboration show promise for the future of motor neurone disease treatment efforts, as protective gene is identified.
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YAP protein identified as new target for Alzheimer’s disease
Researchers have discovered that neuronal necrosis occurs in Alzheimer's earlier than previously though and revealed the YAP protein as a potential target.
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Study identifies brain stiffness as crucial for neurogenesis
A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.
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Oligodendrocyte abnormality identified as potential cause of autism
Researchers have revealed that the disruption of oligodendrocytes, which produce myelin, may be a cause of autism spectrum disorder, so presents a therapeutic target.
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C1 compound identified as promising Alzheimer’s drug candidate
Researchers have screened thousands of drugs to discover that C1 effectively blocks the production of amyloid fibrils, so could be an effective therapeutic.
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Genome screen in mice reveals Huntington’s disease gene target
Researchers have conducted a genetic screen in mice to discover a family of genes that contributes to the development of Huntington's.
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Diabetes-related proteins examined for the first time at high resolution
A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
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Pharmacological chaperone therapy shown to prevent Alzheimer’s in mice
A new study is the first to describe a novel pharmacological chaperone that is capable of preventing Alzheimer's disease in mice.
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Researchers discover how gut infections may produce chronic symptoms
A new study into why neurons in the gut die and how the immune system protects them could lead to better treatments for IBS that work by boosting polyamine production.
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Researchers discover potential diet drug strategy without feeling of nausea
A study has revealed a brain circuit in mice that suppresses the need to eat without a feeling of nausea, presenting a new strategy for diet drugs.
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Novel small molecule could treat Alzheimer’s disease and Dravet syndrome
A new experimental drug was shown by researchers to restore natural brain rhythms in mouse models of Alzheimer’s and promote learning and memory.
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Novel astrocyte target identified to treat drug addiction
Researchers have revealed that astrocytes contribute to reward signalling in the brains of mice, so could be a novel target to treat drug addiction.
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Lower levels of SV2A protein identified as drug target for schizophrenia
Using brain scans, a study has shown that schizophrenia patients have lower levels of the protein SV2A in their brains which presents a drug target.
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Learning and memory of ageing mice improved with stem cells
It has been discovered that cognitive functions such as memory and learning in old mice are improved with more stem cells and neurons.
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Screening platform reveals compounds that protect neuronal mitochondria
Researchers have developed a screening system and identified a set of compounds that protect neuronal mitochondria in mice.
