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An overview of Alzheimer’s disease drug targets
Alzheimer’s disease (AD) is the most common form of dementia which typically occurs after the age of 65 and is characterised by progressive cognitive impairment...
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Neurosciences
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LC3 – Autophagy’s achilles’ heel?
Autophagy is a cellular homeostatic process regulating protein turnover as well as eliciting a stress response to starvation, chemical agents and pathogen infection. It has been implicated in the initiation and progression of several diseases, including neuro-degenerative disorders, Crohn’s disease, infections and cancer...
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Targeting the ubiquitin-proteasome system
The ubiquitin-proteasome system (UPS) is a hierarchical enzymatic cascade that plays an essential role in a broad range of cellular pathways and is found in cytoplasmic and nuclear actions of all eukaryotic cells...
