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Second mechanism of action discovered for COVID-19 drug remdesivir

11 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.

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Epithelial cells found to communicate in two distinct ways

10 May 2021 | By Victoria Rees (Drug Target Review)

Epithelial cell communication depends on the side of the cell, which could have implications for understanding how cancer spreads.

Tubulin protein binding sites discovered through fragment screening

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Simulations and fragment screening reveal binding sites on tubulin protein

7 May 2021 | By Victoria Rees (Drug Target Review)

A combination of computer simulations and fragment screening have uncovered 27 molecular binding sites on tubulin, a protein of the cell cytoskeleton.

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Computational epitope map of SARS-CoV-2 Spike protein developed

7 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have produced a computational simulation of the SARS-CoV-2 Spike protein, finding spots that glycans do not cover.

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Antibodies cover entirety of SARS-CoV-2 Spike protein, study shows

5 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have found that over 80 percent of antibodies target sections of the SARS-CoV-2 Spike protein other than the RBD.

Olink Article Finding a biomarker needle in the haystack

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Article: Finding a (biomarker) needle in the haystack

30 April 2021 | By Olink

Summary of a neurology publication by Alnylam Pharmaceuticals: large-scale protein screening identifies novel biomarker for onset and progression of lethal ATTRv amyloidosis.

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Antibody cocktail shown to neutralise SARS-CoV-2 variants of concern

28 April 2021 | By Victoria Rees (Drug Target Review)

A new antibody cocktail made from three mAbs neutralised several SARS-CoV-2 variants in pre-clinical studies.

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AI platform developed to reveal how bacteria infect intestines

27 April 2021 | By Victoria Rees (Drug Target Review)

A new artificial intelligence (AI) method has been created to uncover which proteins enable bacteria to infect human intestines.

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Nanobody cocktail shown to block SARS-CoV-2 infection in mouse models

27 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have used cryo-EM to show that a new nanobody cocktail can bind to the S protein of SARS-CoV-2, neutralising the coronavirus.

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Compound that targets BRAT1 protein could be used to kill cancer cells

22 April 2021 | By Victoria Rees (Drug Target Review)

Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.

news

Novel COVID-19 vaccine could offer broad protection from coronaviruses

20 April 2021 | By Victoria Rees (Drug Target Review)

A new COVID-19 vaccine could provide protection from severe infection from a range of coronaviruses, studies in pigs have shown.

news

Spikes from AstraZeneca COVID-19 vaccine resemble SARS-CoV-2 S proteins

8 April 2021 | By Victoria Rees (Drug Target Review)

Using cryo-electron microscopy, researchers have shown that the Spike (S) protein on cells exposed to the AstraZeneca vaccine is highly similar to the SARS-CoV-2 S protein.

Hit discovery for GPCRs: HTS or virtual screens?

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Hit discovery for GPCRs: HTS or virtual screens?

8 April 2021 | By Beacon Discovery

Watch our on-demand webinar and learn from an industry expert regarding GPCR virtual screening approaches and challenges and much more.

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Dynamic model of SARS-CoV-2 S protein reveals vaccine targets

7 April 2021 | By Victoria Rees (Drug Target Review)

A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.

Article: Covid Multisystem Inflammatory Syndrome in Children

whitepaper

Article: Multisystem inflammatory syndrome in children with COVID-19

6 April 2021 | By Olink

Children with multisystem inflammatory syndrome have a unique immunological profile revealed by systems-level analyses.

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