news
Scientists uncover mechanism allowing bacteria to survive the human immune system
Researchers have uncovered molecular details of how pathogenic bacteria fight back against the human immune response to infection.
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Protein
news
Tuberculosis: Researchers uncover how bacteria burst our cells
Scientists unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis.
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Developability assessment of therapeutic antibodies
Developability assessment is a broad term covering the evaluation of potential therapeutic candidates’ drug-like properties, manufacturability and safety profile. It is important to carry out this assessment as early as possible in the pre-clinical stage development to select the candidate with the most stable profile. This can minimise the risks…
news
Scandinavian programme launched to produce all human secreted proteins
A new research programme has been launched to produce all the human secreted proteins in mammalian cell factories. The programme aims to facilitate studies of this important class of proteins, which are involved in many human diseases.
webinar
Simultaneous detection of GPCR second messengers in living cells
20 February 2017 | By BMG Labtech GmbH
Due to their role in signal transmission from the outside to the inside of a cell, G-protein coupled receptors (GPCRs) are prominent drug targets.
news
TSRI scientists use ligands to turbocharge drug discovery
Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.
news
New avenue for anti-depressant therapy discovered
Researchers have made a ground-breaking discovery revealing new molecular information on how the brain regulates depression and anxiety.
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Practical application of in vivo optical imaging in biotherapeutic biodistribution analyses
As advances in protein engineering technology have led to the production of novel and more structurally complex biopharmaceuticals, the ability of these drugs to smoothly traverse the body and arrive at their intended target site has become more unpredictable...
whitepaper
Whitepaper: Applications of Bio-Plex Pro™ cell signaling Akt and MAPK assay panels in signal transduction pathways
In this whitepaper, discover the applications of Bio-Plex Pro cell signalling Akt and MAPK assay panels in signal transduction pathways...
news
Novo Nordisk and Aarhus University team up for protein technology R&D
1 July 2016 | By Victoria White, Digital Content Producer
Novo Nordisk and Aarhus University's Science and Technology faculty are to collaborate to strengthen protein technology research and development...
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Mechanism-informed phenotypic screening – the missing link for cancer drug discovery?
Cancer cells exhibit huge phenotypic diversity, with many well-defined phenotypes, such as invasion, deregulated proliferation and immune evasion, contributing to disease outcomes, making them uniquely amenable to phenotypic screening1...
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Advancing FLIP inhibitors for the treatment of NSCLC
26 April 2016 | By Victoria White, Drug Target Review
In an exclusive interview, Trevor Perrior, Research Director at Domainex, discusses the cell death regulatory protein FLIP and the potential of FLIP inhibitors as a treatment for NSCLC...
whitepaper
Whitepaper: Affimer® reagents facilitate affinity chromatography purification of proteins
Purification of tag-free proteins, a vital step for many research and industrial applications...
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Computational methods for drug repositioning
Bioinformatics and computational techniques are now experiencing increased attention as a means of improving the costly and time-consuming drug development process...
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The relevance of homogeneous radiometric assays in modern drug discovery
In the past two decades, several alternative, non-radiometric assay formats have been developed for the high-throughput screening (HTS) of target classes such as protein kinases, which were previously screened using radiometric assays. Radiometric screening (and the expertise to perform such HTS) has thus declined in recent years...
