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LY6E identified as potential immunoprotein against SARS-CoV-2
A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.
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Research & Development
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High-throughput screening reveals 21 drugs with activity against COVID-19
After screening 12,000 existing drugs, scientists have identified 21 which prevent the replication of SARS-CoV-2 in concentrations safe for patients.
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Study reveals microRNA as promising hair regrowth drug target
Researchers have revealed that the microRNA miR-218-5p promoted hair growth in mice, so is a promising drug target for hair loss.
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A circuit involved in itching: from skin to sensory neurons
Dr Santosh Mishra and Srisruti Bontala explain how they discovered a new cutaneous-nerve pathway for allergic itch in atopic dermatitis.
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Researchers identify sEH enzyme as novel Alzheimer’s drug target
A team has shown that inhibiting the soluble epoxide hydrolase (sEH) enzyme in murine models can prevent the cognitive deterioration associated with Alzheimer's.
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Seaweed extract outperforms remdesivir as COVID-19 therapy in vitro
According to new research, sulfated polysaccharides extracted from seaweed were more effective at inhibiting SARS-CoV-2 infection in mammalian cells than remdesivir.
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Breakthrough made in herpes antiviral molecule development
Researchers have created a new method of potentially treating herpes virus, by targeting the physical properties of the viral genome.
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Team redesigns COVID-19 Spike protein for more stable vaccines
Researchers have modified the COVID-19 Spike protein for use in vaccines, which produces up to 10 times more protein than that of an earlier synthetic versions.
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Chloroquine does not prevent SARS-CoV-2 infection in human lung cells, study finds
A new study has shown that while chloroquine protects African green monkey kidney cells from SARS-CoV-2 infection, it does not protect human lung cells.
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Researchers develop potential drug to prevent heart attacks
A novel drug has been created which prevented the blood clotting associated with heart attacks and strokes in pre-clinical studies.
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Five of the most recent microscopy developments
Drug Target Review highlights five of the latest imaging advancements in the field of microscopy.
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Nanoparticle COVID-19 vaccine elicits immune response in pre-clinical studies
The vaccine candidate repRNA-CoV2S elicited both antibody and T cell responses after just two injections in mice and macaques.
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Most antibodies targeting SARS-CoV-2 use specific immunoglobulin subtype
Researchers reveal IgHV3-53 is the most common immunoglobulin mutation used to target the receptor binding domain on the SARS-CoV-2 spike protein.
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Drug side effects: an open source tool to predict adverse reactions
Researchers who developed a machine learning algorithm to predict the adverse effects of new drug compounds have released it as an open source tool.
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Novel bioactive dialysis system improves survival in pigs with acute liver failure
The bioreactor-based system incorporates liver cells to perform the detoxifying functions of the liver and was tested on pigs with acute liver failure.
