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X-ray screening reveals two promising SARS-CoV-2 drug candidates
Using a high-brilliance X-ray lightsource and protein crystallography, researchers have identified two drugs that inhibit the main protease of SARS-CoV-2.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Expanding accessible chemical space through automated high-throughput experimentation
Dr Sam Liver, Manager of the High-Throughput Molecular Discovery Laboratory at the Rosalind Franklin Institute, explains how lab automation in the form of machine learning and high‑throughput experimentation (HTE) can be implemented to enhance productivity in autonomous molecular discovery.
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New in vitro assay developed to test potential NASH drugs
An assay that combines 3D disease models and automated AI-based fibrosis quantification could accelerate NASH drug discovery.
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Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments
In this application note, discover how pools of synthetic crRNAs can produce a phenotype as strong as, or stronger, than any one of the component crRNAs in arrayed CRISPR screening experiments.
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A novel assay to reveal cyclic peptides with affinity to ubiquitin
Although macrocyclic peptides make for promising pharmaceutical candidates, screening for lead peptides has proved difficult for scientists. In a new study, researchers at the Technion-Israel Institute of Technology addressed these challenges by developing a novel high-throughput screening assay for cyclic peptides with affinity to the ubiquitin protein. Drug Target Review’s…
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Product hub: A cost, time and labour-saving protein purification platform
In February 2021, US biotech company GenScript launched an updated version of its semi-automated system, AmMag™ SA Plus.
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COVID-19 drug targets and cell-based assays
The length of time between the administration of a COVID-19 vaccine and evidence of a robust immune response to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) means that treatments are still required. In this article, Sheraz Gul and Alp Tegin Sahin explore the various therapeutic targets that have been identified…
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Application note: Metagenomic analysis of the microbiome with MagMAX
The isolation of microbial DNA is a key prerequisite for determining the microbiome profile of each body habitat.
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Drug Target Review Assays ebook 2021
In this ebook, find articles exploring some of the assays used to identify the most promising COVID-19 drugs and discussing the development of a novel assay to reveal potential peptide therapeutics for cancer.
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Drug Target Review – Issue 1 2021
In this issue, find articles discussing how high-throughput experimentation can enhance automated molecular discovery, why bNAbs present a promising COVID-19 treatment and how a novel rhinovirus vaccine was developed. Also included are features on immuno-oncology, cell line development and assays.
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Whitepaper: Simple Western™ produces publication-ready results
Simple Western™ is an automated capillary immunoassay that produces publication-ready data to meet the highest standards of data integrity and rigor.
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Cell-based assays market set to be worth $22bn by 2025
New research has shown that the cell-based assays market will grow at a CAGR of 8.1 percent between 2020 and 2025.
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Catalogue: Cell isolation with Dynabeads
Magnetic separation with Dynabeads helps ensure that the isolated cells are not affected by passage through a dense column.
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Catalogue: Nuclease-Free tubes, tips & buffers
Working with RNA requires rigorous nuclease contamination controls in place. Stock up on Nuclease-Free tubes tips and buffers #Back2Lab
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Cell-based assay developed to identify IDO1 inhibitors for immuno-oncology
Researchers have developed a cell-based assay for the discovery of new IDO1 inhibitors, overcoming challenges from cell-free assays.
