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Application note: Tools and protocols for high-content imaging and analysis
Integrating hardware, software and fluorescent labels for optimised HCA assay development.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Application note: Laser technology for high-content imaging and analysis
Introducing the CellInsight CX7 LZR High-Content Analysis Platform - an updated version of our CellInsight CX7 instrument with advanced laser technology.
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Application note: Tools for 2D and 3D neuronal cell culture
From the B-27 Plus Neuronal Culture System to fluorescent probes for cell analysis. Publication history of B-27 supplements demonstrates that researchers are expanding its use, far beyond the long-term culture of rat hippocampal and cortical neurons.
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Application note: Fuelling discovery with high-content imaging and analysis
HCA platforms automate image capture and data analysis, giving researchers the sample sizes and precise quantitation tools required for research.
news
Screening for genes to improve protein production in yeast
By silencing genes, researchers have increased the protein production in yeast, laying the grounds for engineering better yeast production hosts for industries producing biopharmaceutical proteins and industrial enzymes.
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HCA: Phenotypic fingerprint of cellular function
High-content analysis app note: Phenotypic fingerprint of cellular function following gene editing by high-throughput imaging acquisition and analysis.
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HCA Application note: New way of measuring synaptic function
High-content analysis: monitoring neurite morphology and synapse formation in primary neurons for neurotoxicity assessments and drug screening.
article
Why do we have no effective treatments for osteoarthritis?
Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4
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Realising the promise of laboratory automation in biomedical research
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
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Therapeutic strategy to prevent gastrointestinal disease
New approach restores epithelial function in diarrhoea and inflammatory bowel disease models...
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Video: High content imaging to examine RNA in cancer cells
Dr Kaylene Simpson, Peter MacCallum Cancer Center, describes their research using high content imaging to examine RNA in cancer cells.
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Video: 3D Culture Screening
Michael Johnson and his team at Visikol talk about the work they do as a contract research organization on 3D Cell Cultures and how they utilize High-Content Analysis / Screening to generate insights.
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Fast molecular interaction screening for all your projects
Current technologies that measure molecular interactions for drug discovery slow down and complicate screening. Dianthus is the answer to the demands for fast, non-stop, highly sensitive hit identification, hit validation and lead optimisation.
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Assays In-Depth Focus 2019
In this In-Depth Focus: the importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays, and why do we have no effective treatments for osteoarthritis?
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Drug Target Review – Issue 1 2019
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
