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Potential indicator for the early detection of dementias
A team of neuropathologists worked together to show that the impairments affecting mitochondria also affect neighbouring organelles...
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Application note: Monitoring receptor ligand binding in living cells
In this application note we will show how a cAMP BRET biosensor can be used to monitor ligand binding with the help of the CLARIOstar microplate reader...
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Genes increasing the risk of triple-negative breast cancer identified
Germ line genetic testing analyses blood samples and evaluates inherited genetic changes that increase the risk of certain cancers in an individual...
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Novel PET imaging could guide therapy for type 1 diabetes
Since beta cells and neurological tissues have common receptors, researchers screened brain radioligands for their ability to identify beta cells...
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Aortic plaques may contribute to liver disease progression
Aortic atherosclerotic plaque inflammation may contribute to the progression of non-alcoholic fatty liver disease to liver fibrosis...
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The evolving role of three dimensional in-vitro cell culture techniques in drug discovery
Drug discovery is a lengthy process that proceeds through several stages. High throughput screening (HTS) utilising whole-cell based screening assays play a fundamental role as a starting point for identifying novel compounds in the drug discovery process.1,2
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Application note: Cellular and biochemical HTRF assays measured in 1536-well microplates
The PHERAstar FSX microplate reader has been developed to meet the requirements for advanced high throughput screening. The new laser for Time-Resolved-Fluorescence (TRF) assays enables fastest read times for measurement in 1536-well microplates while keeping an excellent assay performance...
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Cancer drug screening: the historical perspective
Chemotherapy with cytotoxic and growth inhibitory drugs have played an important role in cancer therapy, used either alone or in combination with other treatment modalities such as surgery, radiation or biological therapy. Chemotherapy, in most instances, was the only alternative treatment for metastatic cancer – mainly given as drug combinations...
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Breath tests could detect pancreatic cancer
Breath tests analysing organic compounds in exhaled breath could be used as a new diagnostic tool for pancreatic cancer...
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Application Note: ATPlite assay performance in human primary cells
ATPliteTM and ATPlite 1step are robust, rapid, high-throughput luminescence assays used to assess a compound’s druggability.
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Whitepaper: A guide to achieving better insight with accurate data
In today’s modern world, data is everywhere. This eBook will guide you through the steps of how to achieve more with accurate data.
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Tech note: Detection of immune checkpoint markers in peripheral blood mononuclear cell lysates with AlphaLISA
Quickly and easily quantitate immune checkpoint markers using a fraction of the sample volume required by traditional ELISAs...
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Video: PHERAstar FSX Customer testimonial
In this video, Becky Allsopp from Sygnature Discovery talks about Drug Discovery Research and how she uses the Microplate Reader PHERAstar FSX for their research.
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Tech note: Fast, simple, homogeneous assays for characterisation of Fc receptor binding using AlphaLISA
AlphaLISA® provides a robust assay that facilitates the design and development of antibody therapeutics.
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Whitepaper: Opportunities in preclinical development
This whitepaper explains how you can find ways to optimise the holistic preclinical development process...
