news
Sanofi and Exscientia establish strategic research collaboration
Sanofi and Exscientia will develop up to 15 novel drug candidates by leveraging the latter's AI discovery and optimisation platform.
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Small Molecules
podcasts
Episode 5 – Small molecule screening with Dr Sheraz Gul, Fraunhofer Institute & Dr John Fuller, Beckman Coulter
In this latest episode, we discuss how small molecule discovery can be automated and how this process saves researchers time and money.
news
Cancer-promoting gene a potential target for pulmonary hypertension
The new study identified PDZ-binding kinase (PBK) as a promising target for pulmonary hypertension and assessed two PBK inhibitors.
news
Nanotechnology boosts immune response at tumour site in mice
The new nanotechnology left six of 10 mice with lymphoma tumour-free and was effective in melanoma when combined with existing drugs.
news
New platform screens for specific class of coronavirus antiviral compounds
Researchers developed a platform that can rapidly screen thousands of compounds to identify potential antiviral drugs to treat coronaviruses.
news
Mechanism that causes ALS nerve destruction unveiled for first time
The study reveals the biological mechanism that causes nerve destruction in amyotrophic lateral sclerosis (ALS), potentially leading to treatments that reverse the disease.
news
Transformable nanoparticles promise advances in tumour treatments
A new study provides an in-depth review on the designs and applications of morphology-transformable nanoparticles to improve cancer therapies.
news
Three RNA-expression states may reveal cancer drug susceptibility
Scientists identified three prototypical RNA-expression states and revealed differences in their susceptibility to a variety of cancer drugs.
news
Scientists discover mechanism that links autism and intestinal inflammation
The new research shows how interleukin-17a (IL-17a) can alter the trajectory of immune system development and cause gut inflammation.
news
Key mechanism reveals how SARS-CoV-2 evades our immune system
Scientists have found that SARS-CoV-2 can knock out an important molecular pathway linked to an immune complex called MHC class I.
news
Targeted nanomedicine reduces vascular lesions in mouse models
The new nanoparticle uses a peptide to target the vascular cell adhesion molecule 1 and reduced the size of vascular lesions in a mouse study.
news
Potent nanoparticle may help improve vaccines for HIV and other diseases
The new nanoparticle adjuvant improved antibody production following vaccination against HIV, diphtheria and influenza in mouse models.
news
Novel screening method identifies lead molecule for GPCR dimerisation
The new high-throughput screening method identified nine lead molecules for rhodopsin dimerisation that may lead to next-generation medicines.
news
HAT proteins could unveil new cancer and Alzheimer’s treatments
The new study used cryo-electron microscopy to visualise the structure of a HAT protein and uncover compounds for drug development.
news
Plant-derived antiviral drug could combat Delta variant
A novel antiviral drug called thapsigargin (TG) blocked COVID-19 infection in cells, including all new variants, in a pre-clinical study.
