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CRISPR-Cas9 repairs genetic mutation in human embryos
"Well thought through and brilliantly executed" study shows different DNA-repair mechanism in embryos compared to iPSCs
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Stem Cells
Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
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New marker could refine the process of producing hPSC-derived insulin cells
Scientists at the University of Copenhagen have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle to purify the cells whose fate is to become cells of the pancreas - including insulin producing cells.
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Blood test for early detection of pancreatic cancer headed to clinic
A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research...
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Development by design methodology: the key to successful manufacturing of patient-specific cell therapies
Recognised as the next wave of medicine, cell therapies have made significant strides over the last several years. But such advancements can present unique challenges, especially as more products move out of the clinic and toward commercialisation. And unlike typical pharmaceuticals, cell therapies rely heavily on the manufacturing process to…
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Hidden herpes virus may play key role in MS and other brain disorders
The ubiquitous human herpes virus 6 (HHV-6) may play a critical role in impeding the brain's ability to repair itself in diseases like multiple sclerosis.
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Genetic DJ: Growing cells remix their genes
Moving genes about could help cells to respond to change according to scientists at the Babraham Institute in Cambridge, UK and the Weizmann Institute, Israel.
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First ‘haploid’ human stem cells could change the face of medical research
Research has yielded the first successful isolation and maintenance of haploid embryonic stem cells in humans.
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New gene mutations found in white blood cells in rheumatoid arthritis patients
Finnish researchers have found that an accumulation of gene mutations, similar to those typically seen in the development of cancer, also occur in some patients with rheumatoid arthritis.
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Scientists uncover how sunlight on skin reduces eczema inflammation
A new study has identified how exposure to sunlight alleviates symptoms of eczema by triggering the release of a compound in the skin that dampens inflammation.
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Blood cell discovery identifies patients with aggressive prostate cancer
Patients who have aggressive prostate cancer could be identified by a highly accurate and simple blood test, according to a new study.
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Cells change type to help or hinder immunity
Scientists have discovered a mechanism that provides a possible new target for allergy treatments, which may bring hope for asthma sufferers.
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Stem Cells In-Depth Focus 2017
Included in this Stem Cells In-Depth Focus: Translating discoveries into therapies; The key to successful manufacturing of patient-specific cell therapies; Interview with Alessandro Prigione and James Adjaye...
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Insights from discovery through clinical efficacy to support a new class of therapeutics in Alzheimer’s disease
Research into innovative small molecule therapeutics with disease modifying potential in Alzheimer’s disease (AD) has been conducted at Alzheon since 2013.
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Scientists give tumour-fighting cells a boost in battling bone marrow cancer
Researchers uncovered a new way to enhance the function of a specific type of immune cell that destroys tumours in multiple myeloma...
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Drug Target Review – Issue #2 2017
Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...
