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Report finds £4.8m of funding contributed to UK health research in 2018
Researchers have found that half of public and charity support for health research over the past 14 years has been for studying the cause and progression of disease.
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Therapeutics
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Kidney stem cells isolated from urine could be the future of regenerative therapies
Research into alternative stem cell sources has identified urine derived renal progenitor cells (UdRPCs) as a possible option for use in regenerative kidney therapies in the future.
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C1 compound identified as promising Alzheimer’s drug candidate
Researchers have screened thousands of drugs to discover that C1 effectively blocks the production of amyloid fibrils, so could be an effective therapeutic.
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Method to make integrin receptor-targeting drugs safer in future presented in study
Research into the structure of the drug-integrin complex has enabled the creation of drugs which inhibit integrin as effectively as currently used compounds, without causing excessive bleeding.
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Influenza B M2 proton channel structure resolved by researchers
Research into the M2 proton channel of influenza B has revealed its structure, which the team hope can aid in the development of targeted therapeutics to block the channel and treat the condition.
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D6PV peptide lowers triglycerides in mouse bloodstream, shows study
Researchers have used a peptide called D6PV to lower triglycerides in mouse models, which could be used as a therapy for high triglyceride-induced acute pancreatitis in humans.
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Imaging technique reveals how HIV drugs bind to viral structure
A new study has shown in three dimensions how drugs bind to HIV, which could be used to improve the design of drugs or develop novel therapies.
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Novel antiviral material made from sugar developed by researchers
Modified sugar molecules have been developed by researchers as antiviral materials which are non-toxic to humans, according to a new study.
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Putrescine could be a therapy for chronic inflammatory diseases
Research has identified that putrescine, which aids macrophages in clearing dead cells, is lacking in atherosclerosis animal models and could be a potential therapeutic for the condition.
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Brain cancer model developed to study glioblastoma
Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.
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Molecular motors used to develop bone marrow-derived mesenchymal stem cells
Researchers have used molecular motors powered by UV light to control the growth of bone marrow-derived mesenchymal stem cells.
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Research into CDK8 oncogene could improve design of future therapeutics
A study has shown that type II kinase inhibitors targeting CDK8 alone are ineffective because mutations leave them inactive, suggesting future therapies should target CDK8 in complex.
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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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PPARγ identified as liver fibrosis ‘off-switch’ in mice
A study identifying transcription factor differences in the hepatic stellate cells of mice with liver fibrosis named PPARγ as a potential target for the condition’s regression and scar resolution therapies.
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Researchers use iPSCs to treat neuropathic pain in mice
Induced pluripotent stem cells (iPSCs) have been administered to mice with neuropathic pain to provide lasting relief with no side effects.
