Light-activated graphene tattoo shows promise in treating heart rhythm disorders
Posted: 28 April 2023 | Drug Target Review | No comments yet
This article outlines the development of the first cardiac implant made from graphene, which is thinner than a single strand of hair yet still functions like a classical pacemaker. It melds softly to the heart to simultaneously sense and treat irregular heartbeats, making it ideal for conforming to soft, dynamic tissues.
The heart is essentially a pump made of muscle, which is controlled by electrical signals. When these signals can become disrupted for several reasons, it can lead to a number of potentially dangerous heart conditions, such as cardiac arrest.
Traditionally, a pacemaker can solve a disrupted heartbeat. It consists of a pulse generator, which emits electrical impulses through the wires to your heart. If the pacemaker senses that your heart has missed a beat or is beating too slowly, it sends signals at a steady rate.
However, new research suggests that a new implant can replace the traditional pacemaker.
Researchers led by Northwestern University and the University of Texas at Austin (UT), US, have developed the first cardiac implant made from graphene, a two-dimensional super material with ultra-strong, lightweight and conductive properties.
Similar in appearance to a child’s temporary tattoo, the new graphene “tattoo” implant is thinner than a single strand of hair yet still functions like a classical pacemaker. Published in Advanced Materials, the study marks the thinnest known cardiac implant to date.
Yet, unlike current pacemakers and implanted defibrillators, which require hard, rigid materials that are mechanically incompatible with the body, the new device softly melds to the heart to simultaneously sense and treat irregular heartbeats. The implant is thin and flexible enough to conform to the heart’s delicate contours as well as stretchy and strong enough to withstand the dynamic motions of a beating heart.
After implanting the device into a rat model, the team demonstrated that the graphene tattoo could successfully sense irregular heart rhythms and then deliver electrical stimulation through a series of pulses without constraining or altering the heart’s natural motions. Even better: The technology also is optically transparent, allowing the researchers to use an external source of optical light to record and stimulate the heart through the device.
“One of the challenges for current pacemakers and defibrillators is that they are difficult to affix onto the surface of the heart,” said senior author Igor Efimov, Professor of Biomedical Engineering at Northwestern’s McCormick School of Engineering and Professor of Medicine at Northwestern University Feinberg School of Medicine.
“Defibrillator electrodes, for example, are essentially coils made of very thick wires. These wires are not flexible, and they break. Rigid interfaces with soft tissues, like the heart, can cause various complications. By contrast, our soft, flexible device is not only unobtrusive but also intimately and seamlessly conforms directly onto the heart to deliver more precise measurements.”
Known as cardiac arrhythmias, heart rhythm disorders occur when the heart beats either too quickly or too slowly. While some cases of arrhythmia are not serious, many cases can lead to heart failure, stroke and even sudden death.
Physicians commonly treat arrhythmia with implantable pacemakers and defibrillators that detect abnormal heartbeats and then correct rhythm with electrical stimulation. While these devices are lifesaving, their rigid nature may constrain the heart’s natural motions, injure soft tissues, cause temporary discomfort and induce complications, such as painful swelling, perforations, blood clots and infection.
With these challenges in mind, the team sought to develop a bio-compatible device ideal for conforming to soft, dynamic tissues. After reviewing multiple materials, the researchers settled on graphene, an atomically thin form of carbon. With its ultra-strong, lightweight structure and superior conductivity, graphene has potential for many applications in high-performance electronics, high-strength materials and energy devices.
“For bio-compatibility reasons, graphene is particularly attractive,” Efimov explained. “It also is flexible and soft, which works well as an interface between electronics and a soft, mechanically active organ.”
Hitting a beating target
At UT, study co-authors Dimitry Kireev and Deji Akinwande were already developing graphene electronic tattoos (GETs) with sensing capabilities. Flexible and weightless, their team’s e-tattoos adhere to the skin to continuously monitor the body’s vital signs, including blood pressure and the electrical activity of the brain, heart and muscles.
However, while the e-tattoos work well on the skin’s surface, Efimov’s team needed to investigate new methods to use these devices inside the body- directly onto the surface of the heart.
“It is a completely different application scheme,” Efimov explained. “Skin is relatively dry and easily accessible. Obviously, the heart is inside the chest, so it is difficult to access and in a wet environment.”
Thus, an entirely new technique was developed to encase the graphene tattoo and adhere it to the surface of a beating heart:
- First, they encapsulated the graphene inside a flexible, elastic silicone membrane — with a hole punched in it to give access to the interior graphene electrode.
- Then, they gently placed gold tape (with a thickness of 10 microns) onto the encapsulating layer to serve as an electrical interconnect between the graphene and the external electronics used to measure and stimulate the heart.
- Finally, they placed it onto the heart. The entire thickness of all layers together measures about 100 microns in total.
The resulting device was stable for 60 days on an actively beating heart at body temperature, which is comparable to the duration of temporary pacemakers used as bridges to permanent pacemakers or rhythm management after surgery or other therapies.
Leveraging the device’s transparent nature, Efimov and his team performed opto-cardiography, using light to track and modulate heart rhythm in the animal study. Not only did this offer a new way to diagnose and treat heart ailments, the approach also opens new possibilities for optogenetics, a method to control and monitor single cells with light.
While electrical stimulation can correct a heart’s abnormal rhythm, optical stimulation is more precise. With light, researchers can track specific enzymes as well as interrogate specific heart, muscle or nerve cells.
“We can essentially combine electrical and optical functions into one bio-interface, because graphene is optically transparent, we can actually read through it, which gives us a much higher density of readout.” Efimov concluded.
Research & Development, Targets, Technology
cardiac arrhythmias, Heart failure
Northwestern University, The University of Texas at Austin
Deji Akinwande, Dimitry Kireev, Igor Efimov