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Scientists have discovered three major pro-inflammatory mediators that drive capillary loss and identified drug combinations to prevent the degeneration of these tiny blood vessels.
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
Mice given a novel drug that targets a key gene involved in lipid and glucose metabolism were able to tolerate a high-fat diet regimen without developing significant liver damage.
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
A new chemical tool has been used to identify hundreds of modified proteins which allows new insights to major diseases.
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
Researchers have found that the TRAP-alpha insulin biosynthesis pathway is essential in both cancer and diabetes, with a common primordial ancestor discovered in C. elegans.
A study has shown that a group of cells called adipose B cells can become dysfunctional with age, causing metabolic conditions such as diabetes, which has provided a drug target.
Scientists in the US have successfully controlled glucose levels in diabetic mouse models without the need for medication.
Researchers have identified a specific receptor that is critical for the release of insulin and provides a target for diabetes and obesity.
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
Scientists combine organ-on-a-chip and stem-cell technologies to make a powerful tool for diabetes research.
Researchers have created a fruit fly model to investigate uric acid-related diseases such as diabetes to aid in drug development.
Researchers have identified a key process behind senescence, or why cells age, which could be used to improve treatments for cancer.
The use of models is a key feature of preclinical studies and in recent months there have been several new advancements in this area. This article investigates five of the latest developments.
