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SEL120: a promising CDK8 kinase inhibitor
A novel CDK8 inhibitor has been developed by scientists at Ryvu Therapeutics. Dr Krzysztof Brzozka showcases this molecule and explains the R&D behind it.
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New study shows insight into how cells maintain their identity
A new study shows the ways in which epigenetic mechanisms control the activity of genes and may have an impact on the future treatment of certain cancers.
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Blocking kinase could provide treatment for prostate cancer
Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.
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Study identifies molecule key in leukaemia treatment resistance
Researchers have found a molecule, which when deleted, increases leukaemia sensitivity to natural killer cells and is a drug target.
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New model found to improve drug development in pre-clinical trials
Researchers have successfully created a multi-organ in vitro model to test toxicity and efficacy of drugs.
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Rare mechanism for ALL to relapse after CAR-T therapy
A single leukemic cell has become resistant to CAR-T therapy after unknowingly engineered with the leukemia-targeting CAR lentivirus...
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Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...
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Researchers uncover up to 100 potential drug targets for cancer
In a new study based on mouse cells, researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.
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Leukaemia protective role of Y chromosome gene discovered
Scientists have discovered the first leukaemia protective gene that is specific to the male-only Y chromosome...
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UFD1 protein responsible for aggressive leukaemia
Researchers have identified a protein critical for the aggressiveness of T-cell leukaemia...
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IPSE protein has potential to alleviate debilitating disease
Chemotherapy-induced hemorrhagic cystitis alleviated by a protein that parasites use to keep hosts alive...
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CRISPR-based system identifies drug targets in AML
Scientists have discovered a way to rein in an overactive protein that drives some aggressive leukaemias...
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HLF gene protects blood stem cells by maintaining them in a resting state
The HLF gene is necessary for maintaining our blood stem cells in a resting state, which is crucial for ensuring normal blood production.
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Drugs targeting the cells circadian rhythm offers hope for glioblastoma
An experimental drug demonstrated selective cancer-killing ability against breast, colon, leukaemia, brain and melanoma cancer cells with no apparent effects on normal cells...
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CRISPR-engineered cancer model to test therapeutics
A new technique for modelling leukaemia may aid drug discovery...