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Combination therapy prevails against BET inhibitor resistance
St. Jude Children's Research Hospital, US, scientists created a new combination therapy method to tackle drug resistance in a type of leukaemia with KMT2A gene rearrangement.
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Leukaemia
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Mouse study at USC reveals why leukemic mutation varies
A mechanism linked to a genetic mutation could help identify patients who are at higher risk of developing leukaemia.
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Researchers discover new compounds to potentially combat leukaemia
Researchers from the US have identified several new small molecules that can induce mitophagy in leukaemia cells.
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Novel CRISPR screen revealed loss of genes in the interferon gamma receptor signalling pathway
A new study has highlighted that the interferon gamma receptor pathway is necessary for CAR T-cell mediated killing in solid tumours.
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Mystery behind odd-shaped blood cancer cells revealed
Researchers have found that the Lamin B1 mutation causes odd-shaped nuclei in blood cancer cells, which may lead to improved care for leukaemia patients.
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Study identifies new therapeutic target for haematologic malignancies
Using chemical genetic screening and pre-clinical model studies, researchers have discovered that inducing ubiquitin-mediated degradation of mutant EZH2 could provide a more effective treatment strategy for haematologic malignancies.
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CRISPR used to model acute myeloid leukaemia progression
CRISPR-Cas9 and stem cell technologies have been used to create a cellular model of acute myeloid leukaemia, revealing therapeutic targets.
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Preventing stem cells from transforming into pre-leukaemia stem cells
Researchers have discovered that two enzymes called APOBEC3C and ADAR1 work together to fuel the transition from pre-cancer stem cells to cancer stem cells in leukaemia.
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Could synNotch CAR T cells be the answer to fighting solid tumours?
Researchers have developed a novel CAR T-cell therapy for neuroblastoma which uses gating to limit toxicity and T-cell exhaustion.
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A novel CAR T-cell therapy to treat lymphomas
A new form of CAR T-cell therapy has shown promise in mice models to treat blood cancers; this article delves into the development behind the therapy.
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CRISPR: three new developments in the world of gene editing
In this article, we outline three recent studies that have advanced the potential uses of CRISPR in the biomedical field.
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Novel class of targeted cancer therapies could treat myeloid leukaemias
Cancer researchers have created a new class of drugs to selectively target and destroy myeloid leukaemia cells with TET gene mutations.
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Scientists identify new way to target leukaemia cells
Researchers have found they can make leukaemia cells vulnerable by dislodging leukaemia stem cells from a tumour-promoting niche.
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Pathway to combat chronic myelogenous leukaemia identified in study
Researchers have discovered that disrupting the Gdpd3 gene significantly reduced chronic myelogenous leukaemia relapse in mice.
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Down syndrome study reveals potential leukaemia drug targets
The study evaluating Down syndrome endothelial cells presented novel drug targets for leukaemia and suggested why DS patients may be at greater risk from the cancer.