PolTREG begins CAR-Treg development for neuroinflammatory disease
After successful completion of the CAR-Treg preclinical study, the first in-human trial of the candidate to treat MS and ALS will commence.
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After successful completion of the CAR-Treg preclinical study, the first in-human trial of the candidate to treat MS and ALS will commence.
Researchers have created a new T cell atlas which could aid the development of novel drug therapies for immune-mediated diseases.
Human brain organoids are complex in vitro tools derived from stem cells, designed to model the molecular basis of neurodevelopment and the pathogenesis of neurological disorders. By mimicking the function of the human brain, in both health and disease, their application in drug discovery holds significant potential for identifying new…
Researchers showed that ESI1, or similar compounds, may help to slow or even reverse cognitive losses that can occur during aging.
Using in situ sequencing, a collaborative research group analysed 260 genes and discovered new sub-structures in MS lesions.
The new findings could lead to a therapeutic target for immune-related disorders, like multiple sclerosis.
Oligodendrocyte precursor cells and the synapses they form with neurons could be relevant to many disease conditions, including cancer.
Data from protein analyses, combined with data from patient journals, enabled the discovery of proteins that predict disease progression.
The new small molecule targets the glutamate system, reducing MS-like symptoms and repairing damaged myelin in two different animal models.
Autologous haematopoietic stem cell transplantation (aHSCT), a medical procedure typically employed in the treatment of blood cancers, holds promise as a potential therapy for individuals with relapsing-remitting multiple sclerosis (RRMS).
Danish researchers undertake a new project that aims to find new forms of treatment for diseases such as MS, which breaks down myelin and nerve fibres, by developing new, artificial nerve fibres
This article highlights five of the latest findings using cell and gene therapy techniques that could be used in the development or design of new therapies.
US researchers have shown that CAR-T therapy can be used to eliminate unwanted cells that cause autoimmunity.
A US researcher studied 3D structures of brain cells and connections, revealing new role for oligodendrocyte precursor cells (OPCs), in mice.
Infusions of purified IL-27 regulatory B cells (I27-Bregs) reduced symptoms in mouse models of multiple sclerosis and autoimmune uveitis.