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Multiple Sclerosis (MS)

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Snapshots of a mouse brain show OPCs nibbling on neurons

1 December 2022 | By Izzy Wood (Drug Target Review)

A US researcher studied 3D structures of brain cells and connections, revealing new role for oligodendrocyte precursor cells (OPCs), in mice.

news

Scientists discover novel B cell that tempers autoimmunity

10 December 2021 | By Anna Begley (Drug Target Review)

Infusions of purified IL-27 regulatory B cells (I27-Bregs) reduced symptoms in mouse models of multiple sclerosis and autoimmune uveitis.

news

Nanobubbles show promise for delivering anti-inflammation treatments

8 October 2021 | By Anna Begley (Drug Target Review)

Nanobubbles known as extracellular vesicles (EVs) were shown to deliver protein drugs in animal models with inflammatory diseases.

Healthy nerve next to nerve with damaged myelin, indicating multiple sclerosis

news

Mechanism discovery provides new model for studying multiple sclerosis

23 September 2021 | By Anna Begley (Drug Target Review)

The over-expression of a growth factor receptor resulted in hypomyelination, leading to diseases such as multiple sclerosis in mouse models.

news

Scientists create cellular blueprint of multiple sclerosis lesions

13 September 2021 | By Anna Begley (Drug Target Review)

An NIH team have built a cellular map of chronic multiple sclerosis (MS) lesions to identify cells that drive inflammation and potential therapies.

news

TREM2 regulation to prevent neurodegeneration is possible, study shows

13 August 2021 | By Anna Begley (Drug Target Review)

Scientists used a synthetic thyroid hormone in mice to regulate the TREM2 gene implicated in diseases such as Alzheimer’s and Parkinson’s.

news

T_reg cells could be answer to multiple sclerosis treatments, say scientists

21 July 2021 | By Anna Begley (Drug Target Review)

New research has shown that the protein Piezo 1 prevented Treg cells from controlling the effects of inflammation in a multiple sclerosis mouse model.

news

Potential peptide to treat multiple sclerosis passes toxicology test

10 March 2021 | By Victoria Rees (Drug Target Review)

A peptide that could treat multiple sclerosis caused no neurotoxicity or cardiotoxic effects in zebrafish, a study has shown.

article

Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration

8 March 2021 | By Hannah Balfour (Drug Target Review)

Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.

T cell overlaid on a test tube - idea of drug discovery for conditions with an immune component, eg, cancer or autoimmune diseases

article

A single approach to creating effective cancer and autoimmune disease therapeutics

8 January 2021 | By Dr H Michael Shepard (Enosi Life Sciences)

Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments.

tablets, syringes and drug vials surrounding the words 'autoimmune disease'

news

Exploration of autoimmune disease target tissues reveals novel drug targets

7 January 2021 | By Hannah Balfour (Drug Target Review)

Researchers suggest that identifying new treatments for autoimmune diseases requires studying the immune system AND target tissues together.

news

Team identifies new potential approach to treat multiple sclerosis

6 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have prevented immune cells from attacking myelin in mice, which stopped the progression of multiple sclerosis (MS).

news

Novel anti-inflammatory slows progression of MS in mice

22 October 2020 | By Hannah Balfour (Drug Target Review)

When delivered intranasally, the anti-inflammatory drug VX-765 prevented axon demyelination and loss in a murine model of multiple sclerosis (MS).

red viruses pouring out of pink human cell

news

Approved MS medication inhibits SARS-CoV-2 replication in vitro

5 October 2020 | By Hannah Balfour (Drug Target Review)

Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.

Patient with multiple sclerosis - Treg therapy

news

T_reg cells could be used in immunotherapy to treat multiple sclerosis, study shows

22 September 2020 | By Victoria Rees (Drug Target Review)

Researchers have discovered how Tregs can reduce spinal cord injury caused by diseases like multiple sclerosis (MS).

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Multiple Sclerosis (MS)