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Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.
Current technologies that measure molecular interactions for drug discovery slow down and complicate screening. Dianthus is the answer to the demands for fast, non-stop, highly sensitive hit identification, hit validation and lead optimisation.
Cell line development is a major step for examining the efficiency of drug discovery, toxicity and in vitro testing. It reduces time, effort and cost, which minimises the chance of research drugs failing at the clinical trial stage. This stage involves the production of recombinant proteins such as monoclonal antibodies,…
A reversal agent that sustains immediate relief from the side effects of ticagrelor stopping major bleeding, such as gastrointestinal hemorrhage...
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
Computational modelling has been used to design proteins that mimic the conserved protein surface of different strains of HIV for use in vaccines...
Researchers have developed a method of using photocathodes and photoanodes to catalyse reactions that turn organic molecules into drug discovery ones...
A novel antiplatelet therapy could help to prevent heart attacks and stroke through preventing the formation of blood clots...
An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...
Small molecule drug discovery has long been the domain of pharmaceutical companies, and that’s not likely to change anytime soon. But there’s a cadre of universities and nonprofit research institutes that have embraced drug development at its earliest stages, in some cases identifying and optimising compounds that target possible disease-driving…
An online compound library consisting of the structure of over a billion molecules could be the future of drug discovery...
The path a metallodrug uses to target and kill cancer cells could be used to design drugs to target triple-negative breast cancer...
Researchers have developed a series of compounds that work not only on AML with common FLT3 mutation but also drug-resistant AML...
Hens that lay human proteins in their eggs could offer hope for future therapies, especially with the simple, cost-effective system used...
