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CRISPR repurposed to develop better antibiotics
Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...
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Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models
Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.
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‘Activating’ the immune system against cancer
A study has found that the immune system can be harnessed to fight cancer cells in a particularly efficient manner, one also effective in lung cancer...
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AI used to diagnose diabetic eye disease
Artificial Intelligence has been used to cost-effectively diagnose diabetic-related eye disease automatically with far more accuracy than current methods...
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Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
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Using machine learning to predict symptoms
Machine learning could, in future, be the way that clinicians decide on particular courses of treatments for patients affected by cancer...
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Application note: Rapidly isolate high-producing clones
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
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Application note: GABAA Receptors
SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.
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Webinar highlights: Integrated fragment based approach reveals enzymatic inhibitors with potential therapeutic application
This webinar, held on 25 October 2018, presented the results from integrated fragment-based approaches for Indoleamine 2,3 dioxygenase 1 (IDO1), an enzyme widely recognised as a drug target for the development of immunotherapeutic small molecules in oncology, unveiling the first ligands able to modulate non-catalytic signalling.
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Webinar highlights: Harmonising drug-target binding data analytics on a single platform
Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.
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Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
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Prolonging antibiotic potency by differentiating between resilience and resistance
Distinguishing whether bacteria are resistant to antibiotics or resilient to them is hugely important in determining the success of the treatment...
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Expert view: Three-dimensional cell cultures as predictive tools in early drug discovery
Three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur…
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Immunoassay developed to detect small molecules
An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...
