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Targeted therapy for treatment-resistant breast cancer
US researchers have uncovered a potential target for treating breast cancer that is resistant to endocrine therapies because of a specific gene mutation.
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3D models used to investigate bacteria motility
US researchers created a 3D model of the bacteria: Helicobacter pylori, to better understand its motility, in order to develop new treatments for bacterial infections.
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Potential pathway to improved stroke recovery
Japanese researchers identify a protein that reduces inflammation, stimulates neural growth, and improves sensory and motor functions following ischemic stroke in mice.
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Diverse senescent cell populations uncovered by single-cell RNA sequencing
Single-cell transcriptomic RNA sequencing analysis has allowed US researchers to identify the specific populations and the dynamic transition states during senescence initiation and progression.
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USC researchers zoom into human genome with mammal DNA
USC researcher Dr Steven Gazal and his team have identified human genome base pairs that have remained constant over millions of years of mammalian evolution. These base pairs are linked to human disease. Using DNA from 240 mammal species, they identified genetic variations affecting an individual's survival and reproduction.
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New insight into BRCA2 gene mutations and cancer risk
A recent study from researchers at the University of California examines the BRCA2 gene, which plays a crucial role in repairing damaged DNA, and possible links with increased risk of breast and ovarian cancer.
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Are tiny brain organoids legally a person?
Japanese researchers debate if human brain organoids that are cultivated from stem cells and serve as a model of human brain development, can be legally considered a person.
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Cancer-killing benefits of popular obesity treatment
Findings from the Republic of Ireland, in relation to GLP-1 obesity treatment showcase its ability to restore the body’s natural cancer-killing defences.
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Antibiotic-resistant bacteria contaminates hospitals’ ICU in China
The drug resistant bacteria: CRAB, came into the ICU in hospitals in Hangzhou, China, creating an urgent need for a thorough understanding of the persistence, transmission, and evolution of CRAB populations in such environments.
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Customising T cell-based immunotherapies to treat cancers
US researchers usings a ‘SNAP’ receptor system can customise immunotherapies for targeted treatments of cancer and other diseases.
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Computational tool gets more out of multi-omics data
US researchers developed a next-generation computational tool called NetBID2 that can uncover difficult-to-identify proteins that drive biological processes contributing to cancer.
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Challenges and promises of personalised precision medicine
Drug Target Review’s Taylor Mixides exclusively interviews Neil Thomas, Partner and Head of Healthcare and Life Sciences for EMEA at Infosys Consulting, on personalised precision medicine, its advances, challenges and the future.
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Special omega-3 fatty acid lipid plays critical role in the ageing brain
Scientists from Singapore have sought to understand the role of Mfsd2a in brain cells, in transporting lysophosphatidylcholine (LPC), a lipid that contains an omega-3 fatty acid
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Helper T cells may hold key to precision allergy treatment
US researchers have connected a rare T cell called Th9 with treating allergies, testing in mouse models with asthma.
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CRISPR and single-cell sequencing highlight genetic variants for traits and diseases
This article highlights a new approach to address human genetics, using STING-seq which provides roadmap to identify variants and genes, enabling deeper understanding of the noncoding genome and targets for therapies
