Researchers reveal how coronaviruses use protein vibrations to enter cells
Using atomistic simulations, a team has demonstrated how coronavirus Spike proteins move and vibrate to let the virus through cell walls.
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Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers
Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.
Compound that prevents replication of SARS-CoV-2 identified by researchers
Researchers say that the Ebselen compound can inhibit the replication of SARS-CoV-2 in the laboratory, so could combat COVID-19.
Mini lung organoids replicate COVID-19 pathology in a dish
Scientists developed a new culture technique for alveolospheres which they used to study how alveolar cells respond to SARS-CoV-2 infection.
Researchers identify potential compound to inhibit inflammation
Researchers have found a compound that can prevent up-regulation of CD14, a key inflammatory protein, in cells.
£4 million in funding announced to collect data on COVID-19 antibodies
UKRI will provide £4 million in funding to establish a data infrastructure for scientists in the UK to study antibodies from COVID-19 patient samples.
CRISPR-based treatment successfully targets glioblastoma and ovarian cancers in vivo
Researchers say this is the first time that CRISPR-Cas9 gene editing has been used to treat cancer effectively in a living animal and that the technique could be revolutionary.
Researchers identify three drugs that could be repurposed for COVID-19
The candidates were screened based on their similarity to hydroxychloroquine and tested for efficacy against SARS-CoV-2 in vitro.
Potential strategy to treat COVID-19-related cytokine storms identified
Researchers have found that neutralising antibodies for the TNF-alpha and IFN-gamma cytokines can prevent death from SARS-CoV-2 in mice.
Novel synthetic method enables production of cytotoxic compounds
Researchers say their new process enables the synthesis of phenazinones, some of which have high selective toxicity for cancer cells and could be promising anticancer drugs in future.
PI3K signalling pathway revealed as potential drug target for obesity
Researchers have found that the PI3K signalling pathway could be targeted to prevent liptoxicity and combat obesity.
Scalable method to image protein levels and changes developed
Using a new CRISPR-Cas9 tagging strategy, researchers have developed a method that enables the imaging of hundreds of proteins in parallel.
Hepatitis C drugs could combat SARS-CoV-2, researchers find
Researchers have identified hepatitis C drugs that can inhibit the SARS-CoV-2 main protease, which enables the coronavirus to reproduce.
Novel technique reveals Parkinson’s changes how neurons sense oxygen
The new approach enables researchers to isolate brain cells associated with Parkinson's disease and study their gene expression patterns.
CBD molecule has potential to treat rare skin diseases, study shows
Researchers have found that CBD induces an enzyme with antioxidant and anti-inflammatory properties in the top layer of the skin.
