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New colon organoids better resemble both healthy and diseased colons
Researchers have developed organoids with naturally occurring early-stage immune cells, which could lead to effective personalised treatment.
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Medical University of South Carolina (MUSC)
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Extracellular vesicles could slow spread of fibrosis
US researchers studied the extracellular vesicles of fibrosis and find potential avenue for new treatments and therapeutics.
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Discovery of CAFs’ origin gives new direction for pancreatic cancer
US researchers discovered a type of cell involved it pancreatic cancer and sheds light on the origin of cancer-associated fibroblasts (CAFs).
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Does treating adolescent acne with systemic antibiotics have unintended consequences on the skeleton?
US researchers unmask the consequences of treating adolescent acne with systemic antibiotics; as it can lead to altered profiles of circulating bile acids that reduce osteoblast function and bone mass accrual.
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STING activation reduces graft-versus-host disease in mouse model
A team has shown that STING activation is a new molecular target in the fight against graft-versus-host disease (GVHD).
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Novel vitamin K analogue eliminates seizure activity in epileptic mouse models
The vitamin K-based drug has a unique structure which researchers believe makes it effective in controlling even medication-resistant seizures.
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Novel complement inhibitor improves ischemic stroke recovery in mice, say researchers
Administering a novel complement protein blocker (B4Crry) alongside reperfusion therapy improved cognitive and motor recovery in a model of ischemic stroke.
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Cervical cancer cell-killing molecule manzamine A found in Indonesian sponge
A study has revealed that a sponge endemic to an Indonesian bay produces manzamine A, a compound which inhibits proteins in cervical cancers.
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Novel pathway to target colorectal cancer identified
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
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Collaborative enzyme study could lead to a target for cancer therapeutics
A new study into the enzyme Cdc34 may make it possible to target the enzyme specifically to develop new cancer therapeutics.
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Natural antioxidant helps improve immune-based therapies
Scientists have discovered a way to improve immune-based treatments by modulating T cells.
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Small molecule factors found to influence age-related bone deterioration
Scientists in the U.S. have reported findings about the mechanisms that contribute to the experience of weaker bones with age.
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Inhibiting NF-κB improves heart function in Duchenne muscular dystrophy
Breakthrough research has uncovered an unexpected mechanism that underlies cardiomyopathy in DMD...