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The Wistar Institute

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DNA vaccine protects non-human primates against MERS, study shows

23 April 2021 | By Victoria Rees (Drug Target Review)

A candidate vaccine has shown potential against MERS in non-human primates, when administered intradermally.

news

RNA protein shown to protect telomeres and support cancer proliferation

15 March 2021 | By Victoria Rees (Drug Target Review)

A team has revealed a function of ADAR1, responsible for RNA editing, discovering an isoform used for cancer growth, making it a drug target.

news

Inhibiting acetate metabolism shows promise in breast cancer model

8 January 2021 | By Hannah Balfour (Drug Target Review)

Inhibiting the ACSS2 enzyme with a molecule called VY-3-135 caused a significant reduction in the growth of breast cancer tumours in vivo.

news

Anticancer activity delivered by targeting mitochondrial cell regulator

4 October 2019 | By Rachael Harper (Drug Target Review)

Disruption of the MFF-VDAC1 complex could lead to a potential therapeutic target for cancer.

news

Potential EBV-associated cancer treatment in small molecule inhibitors

7 March 2019 | By Iqra Farooq (Drug Target Review)

A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...

news

Protection against Mayaro virus using engineered DNA vaccine

8 February 2019 | By Drug Target Review

An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...

news

DNA anticancer vaccine targets tumour neoantigens

24 January 2019 | By Iqra Farooq (Drug Target Review)

A DNA vaccine developed through the use of unique tumour antigens could lead the way towards vaccinating people against cancer...

news

PCSK9 inhibitors to treat high cholesterol

16 November 2018 | By Drug Target Review

Low-density lipoprotein cholesterol could be treated by using synthetic DNA-encoded monoclonal antibodies to inhibit PCSK9...

news

DNA vaccine shows promise for cancer immunotherapy

28 September 2018 | By Dr Zara Kassam (Drug Target Review)

DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...

news

Pro72Arg gene variant increases tumour cell metabolism

1 March 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...

news

Mechanism identified of impaired dendritic cell function that weakens response to cancer

15 December 2017 | By Dr Zara Kassam (Drug Target Review)

New research explains how accumulation of chemically modified lipids interferes with the function of a protein involved in the antitumor function of dendritic cells...

news

DNA-based Zika vaccine found effective at inducing immune response

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...

news

B-cells promote melanoma progression and resistance to therapy

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...

news

Novel immunotherapy technology for prostate cancer

18 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have described a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA...

news

New therapeutic approach for ovarian cancer identified

24 July 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists discover, a potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer...

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The Wistar Institute