Potential EBV-associated cancer treatment in small molecule inhibitors
7 March 2019 | By Iqra Farooq (Drug Target Review)
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
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Protection against Mayaro virus using engineered DNA vaccine
8 February 2019 | By Drug Target Review
An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...
DNA anticancer vaccine targets tumour neoantigens
24 January 2019 | By Iqra Farooq (Drug Target Review)
A DNA vaccine developed through the use of unique tumour antigens could lead the way towards vaccinating people against cancer...
PCSK9 inhibitors to treat high cholesterol
16 November 2018 | By Drug Target Review
Low-density lipoprotein cholesterol could be treated by using synthetic DNA-encoded monoclonal antibodies to inhibit PCSK9...
DNA vaccine shows promise for cancer immunotherapy
28 September 2018 | By Dr Zara Kassam (Drug Target Review)
DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...
Pro72Arg gene variant increases tumour cell metabolism
1 March 2018 | By Dr Zara Kassam (Drug Target Review)
Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...
Mechanism identified of impaired dendritic cell function that weakens response to cancer
15 December 2017 | By Dr Zara Kassam (Drug Target Review)
New research explains how accumulation of chemically modified lipids interferes with the function of a protein involved in the antitumor function of dendritic cells...
DNA-based Zika vaccine found effective at inducing immune response
5 October 2017 | By Dr Zara Kassam (Drug Target Review)
A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...
B-cells promote melanoma progression and resistance to therapy
21 September 2017 | By Dr Zara Kassam (Drug Target Review)
Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...
Novel immunotherapy technology for prostate cancer
18 August 2017 | By Dr Zara Kassam (Drug Target Review)
Scientists have described a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA...
New therapeutic approach for ovarian cancer identified
24 July 2017 | By Dr Zara Kassam (Drug Target Review)
Scientists discover, a potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer...
NIH funds six research collaborations to find a cure for HIV
14 July 2016 | By Victoria White, Digital Content Producer
The US National Institutes of Health has awarded $30 million in annual funding to help advance science towards a cure for HIV...
Inovio and Wistar team up for DNA-based immunotherapies
16 March 2016 | By Victoria White
Inovio and the Wistar Institute are to research preventive and therapeutic DNA-based immunotherapies for cancers and infectious diseases...
PhoreMost and The Wistar team up to identify targets in cancer, immunotherapy and aging
10 March 2016 | By Victoria White
PhoreMost has entered into an alliance with The Wistar Institute to identify and de-orphan novel targets in cancer, aging and the immune system...
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