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The Wistar Institute

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Anticancer activity delivered by targeting mitochondrial cell regulator

4 October 2019 | By Rachael Harper (Drug Target Review)

Disruption of the MFF-VDAC1 complex could lead to a potential therapeutic target for cancer.

news

Potential EBV-associated cancer treatment in small molecule inhibitors

7 March 2019 | By Iqra Farooq (Drug Target Review)

A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...

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Protection against Mayaro virus using engineered DNA vaccine

8 February 2019 | By Drug Target Review

An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...

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DNA anticancer vaccine targets tumour neoantigens

24 January 2019 | By Iqra Farooq (Drug Target Review)

A DNA vaccine developed through the use of unique tumour antigens could lead the way towards vaccinating people against cancer...

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PCSK9 inhibitors to treat high cholesterol

16 November 2018 | By Drug Target Review

Low-density lipoprotein cholesterol could be treated by using synthetic DNA-encoded monoclonal antibodies to inhibit PCSK9...

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DNA vaccine shows promise for cancer immunotherapy

28 September 2018 | By Dr Zara Kassam (Drug Target Review)

DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...

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Pro72Arg gene variant increases tumour cell metabolism

1 March 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...

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Mechanism identified of impaired dendritic cell function that weakens response to cancer

15 December 2017 | By Dr Zara Kassam (Drug Target Review)

New research explains how accumulation of chemically modified lipids interferes with the function of a protein involved in the antitumor function of dendritic cells...

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DNA-based Zika vaccine found effective at inducing immune response

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...

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B-cells promote melanoma progression and resistance to therapy

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...

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Novel immunotherapy technology for prostate cancer

18 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have described a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA...

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New therapeutic approach for ovarian cancer identified

24 July 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists discover, a potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer...

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NIH funds six research collaborations to find a cure for HIV

14 July 2016 | By Victoria White, Digital Content Producer

The US National Institutes of Health has awarded $30 million in annual funding to help advance science towards a cure for HIV...

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Inovio and Wistar team up for DNA-based immunotherapies

16 March 2016 | By Victoria White

Inovio and the Wistar Institute are to research preventive and therapeutic DNA-based immunotherapies for cancers and infectious diseases...

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PhoreMost and The Wistar team up to identify targets in cancer, immunotherapy and aging

10 March 2016 | By Victoria White

PhoreMost has entered into an alliance with The Wistar Institute to identify and de-orphan novel targets in cancer, aging and the immune system...

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The Wistar Institute

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