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Antibodies

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Research reveals antibody treatment pathway for severe allergic asthma

13 October 2017 | By Dr Zara Kassam (Drug Target Review)

Blocking the action of two pro-inflammatory molecules can significantly reduce the symptoms of allergic asthma...

Implementing ADCC assays in QC: When donor variability isn’t an option

webinar

Implementing ADCC assays in QC: When donor variability isn’t an option

6 October 2017 | By DiscoverX Corporation

In this webinar, we discussed how two qualification studies on KILR CD16 Effector Cells demonstrated accuracy and precision in different assays formats.

news

Scientists develop broad-spectrum inhibitors of influenza virus

29 September 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed broad-spectrum inhibitors of the influenza virus using artificial peptide molecules...

whitepaper

Whitepaper: Advancing therapeutic antibody discovery with multiplexed screening

28 September 2017 | By IntelliCyt Corporation

In this whitepaper, IntelliCyt Corporation describe how the iQue Screener is used to perform multiplexed screens for antibody binding to either cell surface or to circulating target antigens...

webinar

Advancing the discovery of immunotherapeutics with large scale multiplexed experiments

27 September 2017 | By IntelliCyt Corporation

In this webinar, Belen Ybarrondo, Ph.D and Thomas Duensing, Ph.D discuss the challenges faced with antibody screening and how the iQue Screener can give an evaluation of cell killing mechanism, screening for immune checkpoint inhibitors and more...

news

B-cells promote melanoma progression and resistance to therapy

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...

news

Three-in-one antibody may protect from HIV-like virus

20 September 2017 | By Dr Zara Kassam (Drug Target Review)

A three-pronged antibody has been found to protect from infection with two strains of SHIV, better than individual natural antibodies...

whitepaper

Application note: Characterising chemokine receptor inhibitors with Alpha SureFire Ultra assays

12 September 2017 | By Daniel Cardillo, Jeanine Hinterneder, Matthew Marunde, Vincent Dupriez

In this application note, PerkinElmer discuss how their ValiScreen CXCR2 GPCR cell line (#ES-145-C) was utilised to examine the downstream effects of chemokine receptor modulation using multiple blocking antibodies and a small molecule...

news

Antibody targets create potential for a unified treatment approach

29 August 2017 | By Dr Zara Kassam (Drug Target Review)

Antibody targets thought to cause the most damage in neurological disorders, creates potential for a unified treatment approach...

news

New imaging technique may predict the of spread breast cancer

16 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a radioactive ‘tracer’ molecule to detect myeloid-derived suppressor cells’ accumulating in the lung in preparation for the arrival of breast cancer cells...

news

Novel immuno-oncology treatment for patients with advanced solid tumours

10 August 2017 | By Dr Zara Kassam (Drug Target Review)

An experimental immuno-oncology treatment will move into early phase clinical trials for patients with advanced solid tumours...

news

VRC01 antibody may prolong time to HIV viral rebound

26 July 2017 | By Dr Zara Kassam (Drug Target Review)

A study has shown the infusion of a broadly neutralising antibody (VRC01) in virally suppressed volunteers associated with a modestly delayed rebound of HIV...

news

Scientists discover how membrane necks get constricted and cut

10 July 2017 | By Niamh Marriott (Drug Target Review)

Scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have succeeded in revealing a key mechanism of membrane deformation.

news

AbCellera expands research collaboration with Teva

19 June 2017 | By Niamh Marriott (Drug Target Review)

Collaboration extends initial partnership and aims to generate lead antibody candidates against membrane targets using AbCellera's antibody discovery platform…

news

Numab and Kaken enter into an antibody collaboration

15 June 2017 | By Niamh Marriott (Drug Target Review)

Numab Therapeutics announced a collaboration and option agreement with Kaken Pharmaceutical for the identification of a multispecific antibody candidate for development in inflammatory disease.

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Antibodies