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Anle138b blocks toxic ion flow linked to Alzheimer’s disease
A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease by stopping toxic ion flow in the brain...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Inhibiting METTL3 destroys AML cells without harming normal blood cells
An unexpected drug target for acute myeloid leukaemia could open new avenues to develop effective treatments against the potentially lethal disease...
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CXCL5 protein found to stimulate tumour growth in prostate cancer
Researchers identify a pathway that causes tumour acceleration in metastatic prostate cancer cells...
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pIC found to prevent the development of liver cancer
A synthetic double-stranded RNA has potential for use as an anti-liver cancer vaccine...
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Declines in plasticity reveal promising targets for Alzheimer’s disease
Brain changes linked to memory loss may provide a new focus for exploring ways to treat or prevent dementia...
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Key psychiatric drug target comes into focus
Researchers have reported a major step forward towards designing more powerful psychiatric drugs with fewer side effects...
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CRISPR used to identify drug target for bowel cancer
CRISPR used to identify a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies...
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Potential targets for treatment of leishmaniasis identified
Brazilian scientists show that parasite's penetration of host cells increases expression of certain microRNAs capable of inhibiting the action of the immune system...
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DNA-based Zika vaccine found effective at inducing immune response
A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...
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NRF2 pathway provides new approach to cancer drug discovery
Scientists have developed a promising new strategy for the discovery of novel anti-cancer therapies for non-small-cell lung cancers...
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Scientists develop broad-spectrum inhibitors of influenza virus
Scientists have developed broad-spectrum inhibitors of the influenza virus using artificial peptide molecules...
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Novartis and UC Berkeley collaborate to tackle ‘undruggable’ disease targets
Collaboration aims to unlock difficult drug targets and accelerate the discovery of new medicines in areas such as infectious diseases and cancer...
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Streamlined process opens drug development to a new class of steroids
Researchers have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries...
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Potential therapeutic protein inhibitors for Chagas disease
Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...
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Calcilytics as potential novel therapeutic treatments to halt Alzheimer’s disease
Alzheimer’s disease (AD) is the most prevalent form of dementia.1 The common (>95% of cases) slow-developing form of the ailment is known as late-onset AD (LOAD) or sporadic AD (SAD). The rare (
