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Discovery of novel mechanism for MRSA virulence
US researchers revealed that MRSA has undergone repeated mutations in the sarZ gene, leading to increased severity of blood stream infections in mouse models.
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Gene Testing
Gene testing is a type of medical test that identifies changes in chromosomes, genes, or proteins.
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New method precisely locates gene activity and proteins across tissues
The scientists argue the technique enables the creation of complex, data-rich “maps” of organs, including diseased organs and tumours, which could be widely useful in pre-clinical research.
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Drug Target Review’s top content picks from 2022
In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.
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P53 could be key to therapies for salivary gland cancer
Mouse models show that activating a non-mutated form of the gene could lead to developing therapies for salivary gland cancer.
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Pattern of gene activity for ADHD is unlocked
US researchers identified that those with ADHD have differences in gene activity in the brain.
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New control system created for synthetic genes
MIT researchers have developed a technique that could help the production of monoclonal antibodies and other useful proteins.
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Researchers find that reduction in protein synthesis could lead to Feingold syndrome
The researchers used a zebrafish model to test mutations in Mycn, a gene which causes Feingold syndrome.
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Neonatal ketone body determines premature ovarian ageing
The researchers found that ketone body deficiency in neonatal mice resulted in smaller ovarian follicle reservoir because of the increased apoptosis of primordial follicles.
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Gene Lx9c11 helps mice survive virus infections
Researchers have discovered that “jumping gene” Lx9c11 has a profound effect on the immune system to virus infection.
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Researchers find that CRISPR gene editing can give rise to cell toxicity and genomic instability
Using computational methods, researchers analysed the most popular CRISPR library designed for human cells and found 3,300 targeted spots that show strong toxic effects.
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Progress towards a stem cell-based therapy for blindness
Scientists are developing an effective stem cell-based therapy to regenerate photoreceptors cells and restore sight in people with blindness.
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Study reveals potential therapeutic targets for pancreatic cancer
Researchers analysed the expression of long non-coding RNAs in samples from patients and tumour cell lines, identifying a group of genes with augmented expression in pancreatic cancer.
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Research shows that EBAG9 leads to strengthened immune response to cancer
The scientists say that shutting down the EBAG9 gene allows the body to destroy tumour cells earlier and more radically.
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Visualising mRNA molecules in the brains of living mice
Scientists have developed a new imaging technique that allows researchers to see gene expression and mRNA molecules in the brains of live mice in real time.
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Using organoids to identify drugs for autosomal dominant polycystic kidney disease
Scientists generated kidney organoids and used them to identify potential drugs to treat autosomal dominant polycystic kidney disease.