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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
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Immunology
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Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Vaccine signatures point to a better understanding of infectious diseases
Researchers have developed a comprehensive way to evaluate how immune responses of humanised mice measure up to actual humans...
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Stimulating fibroblasts can trigger hair growth in wound healing
Stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing...
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Majority of HIV persistence during ART due to infected cell proliferation
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure...
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Scientists test new anti-PD-L1 cancer vaccine against melanoma
An experimental cancer vaccine that boosts the immune system's ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumours, scientists have reported...
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Tethered antibodies may prevent influenza virus infections
Investigational therapeutic candidate made with four antibodies tethered together shows promise against influenza A and B...
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Nonresponsive NK cells directly impact malaria severity
The failure of natural killer cells (NK cells) to respond to infection explains why malaria causes a worse reaction in some patients than others.
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Alpaca immune system reveals a potential treatment for cancer
Researchers have identified camelid nanobodies that are able to block EGF, a protein that is abundant in tumour cells...
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Cancer vaccine shows promise for HER2-positive cancers
Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers...
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Synthetic biology in drug discovery
Synthetic biology is broadly defined as the design and construction of novel artificial biological pathways, organisms or devices; or the redesign of existing natural biological systems.1 It brings together a range of disciplines and skills, from biology and chemistry to computing, bioinformatics and engineering.
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What happens to skin cells when they are confronted with blood?
Researchers have performed experiments on blood-deprived cells that were subsequently exposed to blood serum, revealing new insights into the mechanisms of wound healing...
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Expert view: New developments in real‑time live‑cell analysis
Live-cell analysis is now a well-established method that is part of the everyday cell biologist’s armoury for understanding cell biology. For over a decade, the functionality, throughput, and ease of use offered by real-time live-cell analysis has provided a platform for accurate and reproducible cell biology analysis in multiple biomedical…
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NanoMIPs efficiently target and eliminate cancer cells
A joint research team has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs...
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Blood test may identify cancer patients who won’t respond to immunotherapy
Patients who are unlikely to benefit from a commonly used immunotherapy for bladder cancer could be identified by a simple blood test...
