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Takeda enters agreement with F-star Therapeutics to license bispecific antibody
F-star Therapeutics has announced a licence agreement with Takeda for a novel next-generation immuno-oncology bispecific antibody.
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Immunotherapy
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Whole exome sequencing predicts whether cancer patients will respond to immunotherapy
Researchers have developed a two-step approach using whole exome sequencing to focus on genes and pathways that predict whether cancer patients will respond to immunotherapy.
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Scientists map networks of disease-associated immune genes
The new immune gene networks have implications for developing immunotherapies and understanding autoimmune diseases.
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How the innate immune system detects HIV-1
Researchers have found that the innate immune system requires two steps to defend against HIV-1, even when the virus is present in small amounts.
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New immune targets to improve survival from sepsis
In a pre-clinical study, researchers from the US set out to develop a treatment for sepsis. Here, Daniel Morales-Mantilla, Dr Robin Parihar and Dr Katherine King, from Baylor College of Medicine, describe how they utilised haematopoietic stem and progenitor cell infusion to improve the survival of mice from sepsis.
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Listeria-based booster improves vaccine’s protection against recurring cancer
New research has shown that using viral and bacterial vaccine approaches together is safe and far more effective at fighting the cancer than either approach by itself.
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How tumours change immune cells to promote cancer growth
Researchers have found that soft-tissue sarcomas change the biology of immune cells surrounding tumours to promote tumour growth
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New combination therapy exploits ‘natural killer’ cells to destroy head and neck tumours
Scientists have identified a new treatment combination that is highly effective at suppressing the growth of head and neck tumours.
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Global team aims to bring next generation CAR T-cell therapies to children with solid tumours
The Mark Foundation for Cancer Research awards ~$12 million to Cancer Grand Challenges Team to develop new immunotherapies for childhood solid tumours.
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Immunity boosting treatment enhances CAR T-cell therapy for blood cancers
A new study in mice has shown blood cancer treatment with protein interleukin-7 revs up T-cell immunotherapy.
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Using immunotherapy to prevent cancer metastases
Scientists have demonstrated how killer T cells used in immunotherapy to eliminate cancer cells can also destroy tumour lymphatic vessels, thus greatly reducing the risk of metastasis.
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Novel CRISPR screen revealed loss of genes in the interferon gamma receptor signalling pathway
A new study has highlighted that the interferon gamma receptor pathway is necessary for CAR T-cell mediated killing in solid tumours.
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Cancer immunotherapy capable of regulating tumour immunophenotypes
Researchers have found that small-molecule activation of innate immunity induces the infiltration of immune cells into cancer cells.
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New prostate cancer subtype may illuminate treatment strategy
Researchers have identified a previously unrecognised form of hormone therapy-resistant prostate cancer.
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Ultrasound-guided microbubbles boost immunotherapy efficacy
Researchers have developed an immunotherapy platform to improve both antitumor immune responses and responses to checkpoint inhibitors
