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Controlling PTEN gene could combat paediatric rhabdomyosarcoma

20 September 2021 | By Anna Begley (Drug Target Review)

The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.

Older man with dementia sitting with nurse

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Researchers identify specific drug targets for a variety of brain disorders

17 September 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered drug targets in the neural circuits that encode memories, paving the way for the treatment of brain disorders.

Flyer: Introducing Eurofins Beacon Discovery; the GPCR experts

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Flyer: Introducing Eurofins Beacon Discovery; the GPCR experts

17 September 2021 | By Eurofins Discovery

Learn how you can partner for success with Eurofins Beacon Discovery’s industry leading GPCR experts to support your program from concept to clinic.

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MEPs demand action plan to end animal testing in Europe

16 September 2021 | By Anna Begley (Drug Target Review)

MEPs have requested that the EU adopts new plans to phase out the use of animals in scientific research and testing, focusing on alternatives instead.

news

Scientists reveal that glioblastoma shows dependency on biotin distribution

15 September 2021 | By Anna Begley (Drug Target Review)

Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.

news

Gene therapy for Morquio A disease successful in rat model

14 September 2021 | By Anna Begley (Drug Target Review)

A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.

Microphage immune cell engulfing bacteria

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Immune cells found co-operating to capture and “eat” bacteria

13 September 2021 | By Anna Begley (Drug Target Review)

Researchers have identified a spider-like antibacterial mechanism by immune cells that could inspire Staphylococcus aureus treatments.

news

Scientists create cellular blueprint of multiple sclerosis lesions

13 September 2021 | By Anna Begley (Drug Target Review)

An NIH team have built a cellular map of chronic multiple sclerosis (MS) lesions to identify cells that drive inflammation and potential therapies.

Pregnant woman having her blood pressure taken

news

PP2A enzyme could be major driver of preeclampsia

10 September 2021 | By Anna Begley (Drug Target Review)

A new study found that protein phosphatase 2 (PP2A) found to be a major driver of preeclampsia, potentially leading to treatments.

news

S1P may be a potential target for cerebral blood alterations

9 September 2021 | By Anna Begley (Drug Target Review)

Sphingosine-1 phosphate was found to regulate blood glow in cerebral blood vessels in mice, presenting a potential therapeutic target.

news

Scientists discover mechanism behind cardiac hypertrophy

6 September 2021 | By Anna Begley (Drug Target Review)

New research has uncovered a mechanism underlying cardiac hypertrophy in mice, spurring novel avenues for potential treatments.

news

Genetic defect in IBD patients linked to gut leakiness

6 September 2021 | By Anna Begley (Drug Target Review)

A genetic defect in patients with inflammatory bowel disease (IBD) was found to affect how intestinal epithelial cells maintain a barrier.

news

IAIPs shown to reduce ischemic stroke damage in pre-clinical study

2 September 2021 | By Anna Begley (Drug Target Review)

Inter-alpha inhibitor proteins (IAIP) demonstrated efficiency in reducing damage from an ischemic stroke, reveals pre-clinical study.

news

Controlling HSP27 “switch” could be key to sepsis therapeutics

1 September 2021 | By Anna Begley (Drug Target Review)

Study reveals that the HSP27 protein plays a role in regulating blood vessel leakage, providing new targets for drugs against sepsis.

news

DNA mechanism discovery may open up Huntington’s disease therapies

1 September 2021 | By Anna Begley (Drug Target Review)

Scientists unveiled how a DNA repair protein may prevent Huntington’s disease, presenting a new target in future therapies.

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