Clues discovered for why MYH9 gene mutations cause human disorders
A new study has demonstrated for the first time that mutations that affect myosin motor activity result in slower cell movements in vivo.
List view / Grid view
A new study has demonstrated for the first time that mutations that affect myosin motor activity result in slower cell movements in vivo.
Researchers discover that a non-coding region of the genome originates a key molecule for the proliferation of cancerous tumours.
Researchers have identified a protein that plays a role in promoting blood cancer and have successfully used a novel compound to inhibit it, reducing tumour growth.
For biomarker discovery efforts, primary cell assays, and patient-derived xenograft work, among others, access to fresh human surgical tissue is an essential component in obtaining reliable results.
Researchers have successfully created a multi-organ in vitro model to test toxicity and efficacy of drugs.
Researchers announce positive pre-clinical results for two sickle cell disease treatment strategies.
This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.
Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.
New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.
A stem cell therapy rectifying the FoxP3 gene has been developed to treat IPEX, and has virtually cleared symptoms of the condition in mice...
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
Three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur…
Reporter gene assays have greatly helped our understanding of gene regulation and signal transduction in vitro and in vivo.
Mouse models used to show how convection enhanced delivery caused glioma cells to invade the rest of the brain could help to prevent this spread in future...
Team of oncology experts expand data in Tumor Model Compendium and present strong portfolio at industry conferences...