news
Very long-chain fatty acids found to block SARS-CoV-2 infection
Researchers have shown that omega-3 very long-chain polyunsaturated fatty acids can block SARS-CoV-2 and protect lung cells.
List view / Grid view
Lipids
news
Lipid droplets may prevent kidney damage from high-fat diets
Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.
article
Protecting liposomes in COVID-19 mRNA vaccines could increase their stability
A team from the University of Texas at Dallas has shown that a novel buffer solution is effective at stabilising the liposomes and lipid nanoparticles in certain COVID-19 vaccines.
article
Synthesising very long-chain fatty acids to treat retinal conditions
A class of lipids – or fatty acids – found in the retina of the eye play an important role in maintaining vision. Victoria Rees, Deputy Editor of Drug Target Review, spoke with Dr Paul Bernstein from the Moran Eye Center at the University of Utah, US, to discover how…
news
Blocking Treg pathway sensitises mice to immunotherapy
Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
news
PI3K signalling pathway revealed as potential drug target for obesity
Researchers have found that the PI3K signalling pathway could be targeted to prevent liptoxicity and combat obesity.
news
Could a sphingosine nasal spray prevent COVID-19?
According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.
news
Pathway to combat chronic myelogenous leukaemia identified in study
Researchers have discovered that disrupting the Gdpd3 gene significantly reduced chronic myelogenous leukaemia relapse in mice.
webinar
Drug repurposing approaches to fast track development of new therapies for COVID-19
26 June 2020 | By Tecan
This webinar described the recent efforts to identify small molecule therapeutics for the treatment of SARS-CoV-2 infection and COVID-19 disease.
news
Novel compound improves symptoms of fatty liver disease in mice
The novel peripheral serotonin antagonist, based on Parkinson’s drug pimavanserin, increased glucose tolerance and lean body mass in a murine model of non-alcoholic fatty liver disease (NAFLD).
whitepaper
Application note: Monitoring of SMALP-nanodisc formation by microfluidic diffusional sizing
29 May 2020 | By Fluidic Analytics
Styrene–maleic acid (SMA) copolymers have become popular tools used in membraneprotein research as they can extract both lipids and membrane proteins from cellular membranes while preserving the bilayer structure of the membrane in so-called nanodiscs.
news
Lipid mediators suggested as potential COVID-19 inflammation treatment
A new article has outlined the body's inflammatory response to COVID-19 infection, saying that lipid mediators derived from omega-3 fatty acids could prevent life-threatening inflammation.
news
Software developed by researchers accelerates analysis of lipids
A novel software made by scientists can be used for the analysis of specific lipid groups and lipid signal molecules which can enable their characterisation with mass spectrometry.
news
Chemical tool developed to examine lipids in living cells
A new method has been developed by researchers using chemical tools activated by light to influence lipid concentration in living cells.
whitepaper
Whitepaper: The first bioactive Wnt1 protein – purification of Wnt1/sFRP complexes
Wnt proteins have been extremely difficult to purify in an active state due to their hydrophobic nature arising from post translational lipid modifications.
