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Chemical tool developed to examine lipids in living cells
A new method has been developed by researchers using chemical tools activated by light to influence lipid concentration in living cells.
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Lipids
whitepaper
Whitepaper: The first bioactive Wnt1 protein – purification of Wnt1/sFRP complexes
Wnt proteins have been extremely difficult to purify in an active state due to their hydrophobic nature arising from post translational lipid modifications.
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Structure of lipin enzyme responsible for triglycerides revealed for first time
Researchers have obtained the crystal structure of the lipin enzyme, the regulator of triglyceride production, which they say could inform research into heart disease, obesity and diabetes.
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Innate protein restricts HIV replication by targeting lipid rafts
According to a new study, apolipoprotein A-I binding protein restricts HIV-1 replication by targeting lipid rafts and reducing virus-cell fusion.
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Missing link found in rare inherited skin disease
Scientists are getting closer to understanding how a rare hereditary disease impairs the skin's barrier function, which determines how well the skin is protected.
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Cancer metastasis can be prevented by stopping lipid storage in mice
A study has demonstrated the aggressiveness of cancers is promoted by their ability to store fatty acids in lipid droplets; this discovery could lead to new anti-metastasis therapies.
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Therapeutic target found for diseases caused by lipid accumulation in cells
Researchers have identified the protein Annexin A6 as a potential therapeutical target against diseases that are caused by the accumulation of cholesterol and other lipids in endosomes.
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New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
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Method developed for quicker and simpler production of lipidated proteins
A simple and direct method of introducing lipids into protein has been developed using palladium as a catalyst.
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Lipid accumulation in the brain may be an early sign of Parkinson’s disease
A collaborative team of researchers has found that elevated levels of certain types of lipids in the brain may be an early sign of Parkinson's...
article
The next revolution in stratified medicine: molecular phenotyping with metabolomics
The study of biochemistry provides molecular insights into how the human population ages, how diseases commence and progress, how molecular changes relate to disease remission and relapse, and how humans respond to treatments...
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Pharmacometabolomics as the key to personalised medicine
Blanketed administration of drugs to all populations assumes that all patients respond similarly. Despite pharmaceutical companies’ efforts to develop drugs with large therapeutic windows, there are often and inevitably subpopulations of individuals who will either not respond to therapy or will respond with adverse effects...
