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Drug target to halt progression of Parkinson’s disease identified
Scientists have shown that trapped LC3B protein in brain cells enables Parkinson's disease to spread, presenting a drug target.
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Neurosciences
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Gene therapy in Alzheimer’s mouse model preserves learning and memory
A new gene therapy that introduced SynCav1 to the brains of Alzheimer's mouse models was shown to preserve neuronal and synaptic plasticity.
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New label-free imaging method created to visualise brain samples
A novel sensitive label-free imaging method has been developed to visualise brain samples using an FxClear-based tissue clearing technique.
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Experimental drug shown to reverse effects of Alzheimer’s in mice
Oral doses of a new drug named CA administered to mouse models led to improvements in Alzheimer's disease, including memory.
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Stem cell therapy repairs damage from dementia in mouse brains
Researchers have developed a stem cell therapy that could treat the damage caused by dementia by launching a repair response.
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Reduced levels of H2S in rat brains protects against dementia
A study has shown that treatments to reduce levels of hydrogen sulphide (H2S) in the brain may help to prevent dementia.
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Team sheds light on the co-ordination of neural stem cell activation
Scientists have visualised the spatial and temporal distribution of neural stem cell activation in zebrafish models.
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Team reveals miR-29 as regulator of processes for normal brain maturation
Researchers have shown that miR-29 can control brain maturation in mammals, presenting a target for autism, epilepsy and other conditions.
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New drug target identified to potentially fight neuroblastoma
Researchers have revealed that the protein ALYREF promotes the effects of the neuroblastoma gene, MYCN, making it a target.
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Polymerised oestrogen provides neuroprotection in pre-clinical study
The polymerised form of oestrogen has shown success in mice at preventing further damage to the spinal cord after injury.
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‘Zinc finger’ gene therapy could help to treat Alzheimer’s disease
Promising results have been shown in an animal model of Alzheimer's disease treated with zinc finger protein transcription factors.
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Cannabinoids could reduce essential tremors in patients
A synthetic cannabinoid has shown promise as a treatment for involuntary tremors by activating astrocytes in mouse models.
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Rhesus macaque model of Alzheimer’s disease developed
Scientists have developed a model of the early stages of Alzheimer's disease in rhesus macaques to better test new treatments.
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Nano-micelles used in CRISPR genome editing of mouse brains
Researchers have reported that nano-micelles can be used to efficiently deliver CRISPR-Cas9 to edit genes in the brains of mice.
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Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration
Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.
