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Researchers prevent schizophrenia progression in mice
Using mice models in late adolescence, researchers have successfully treated schizophrenia which could help develop therapies for the condition.
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Neurosciences
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Drug Target Review – Issue 3 2019
This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing.
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Five recent Parkinson’s disease drug target discoveries
This article highlights five of the latest findings that could be used in the development or design of new therapies to treat Parkinson’s disease.
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Medical Research Council updates brain tissue database
The UK Brain Banks Network has been enhanced to include genomic data, which can be accessed by researchers worldwide.
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Scientists identify promising new target to combat Alzheimer’s disease
New research is the first to link maladaptive changes in calcium transport by mitochondria to the progression of Alzheimer's disease.
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Stem cell division in the geriatric brain blocked by signal
It has been discovered that Id4 controls whether stem cells enter cell division and may be relevant for treating neurodegenerative disease.
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Collaboration to discover MND treatments announced
MSD and the Francis Crick Institute will work together on a project to identify disease targets for motor neuron disease.
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Revealed autophagy mechanism is potential dementia target
A study has discovered the regulating process behind cell autophagy which could aid in the development of neurodegenerative disease treatments.
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Link between immune cells and Alzheimer’s discovered
Researchers have found that the presence of microglia brain cells allowed plaques to form in the brains of rodents, leading to Alzheimer’s disease.
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Researchers identify potential drug target for depression in primates
A study has discovered a molecule key in neuronal growth that could be used as a drug target to treat anxiety-related diseases.
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Nanotechnology platform could improve stem cell transplantation
A team has developed a technique for identifying pluripotent stem cells that could help research on transplantation medicine.
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Motor neuron disease electrical signalling pathways mapped
A study has used EEG to investigate the neuron networks that act abnormally in the condition, providing a significant step in the search for treatments.
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Encouraging drug discovery and therapeutic targets for dementia
A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.
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Tauopathy-regulating protein identified
Researchers have discovered that the VPS35 molecule can be utilised in preventing neurodegenerative disorders.
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First patient enrolled in Parkinson’s treatment study
A trial has begun in the US for the ENT-01 therapy treatment of Parkinson’s, with the first patient enrolled.
