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Although macrocyclic peptides make for promising pharmaceutical candidates, screening for lead peptides has proved difficult for scientists. In a new study, researchers at the Technion-Israel Institute of Technology addressed these challenges by developing a novel high-throughput screening assay for cyclic peptides with affinity to the ubiquitin protein. Drug Target Review’s…
In this ebook, find articles exploring some of the assays used to identify the most promising COVID-19 drugs and discussing the development of a novel assay to reveal potential peptide therapeutics for cancer.
A peptide that could treat multiple sclerosis caused no neurotoxicity or cardiotoxic effects in zebrafish, a study has shown.
A high-throughput screening assay for macrocyclic peptides with affinity to ubiquitin has been created by researchers.
A peptide administered to ferrets protected them from SARS-CoV-2 viral transmission when housed with infected ferrets.
A novel nanotherapy can decrease intestinal inflammation and shrink lesions in rodent models of Crohn's disease, a study has shown.
Researchers have synthesised peptides that function like a soluble chemokine receptor, blocking atherosclerosis in animal models.
New research has shown that 'hidden' lysis genes in bacteriophages could be used in the development of a new class of antibiotics.
A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.
Researchers report that their LEAPS COV-19 peptides significantly improved survival in a murine model of COVID-19.
A team fused the peptide somatostatin to a brain transport protein and found it treated memory loss associated with Alzheimer's in mice.
Researchers have found that CBD reduces inflammation in the lungs of COVID-19 mouse models by increasing levels of the apelin peptide.
An analysis of SARS-CoV-2 has allowed researchers to identify epitopes recognised by a large fraction of COVID-19 patients, with 10 that could be targeted by antibodies.
Scientists have found a hormone peptide called YY that presents a promising drug target for malabsorption in babies.
The Spike (S) protein is a promising drug target in the quest to develop vaccines and antivirals for SARS-CoV-2 to treat and prevent COVID-19. Intra-protein interaction energy landscape mapping efforts have recently identified key interactions that may be crucial for the S protein’s ability to bind to receptor proteins on…
