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Scientists discover mechanism behind cardiac hypertrophy

6 September 2021 | By Anna Begley (Drug Target Review)

New research has uncovered a mechanism underlying cardiac hypertrophy in mice, spurring novel avenues for potential treatments.

news

Genetic defect in IBD patients linked to gut leakiness

6 September 2021 | By Anna Begley (Drug Target Review)

A genetic defect in patients with inflammatory bowel disease (IBD) was found to affect how intestinal epithelial cells maintain a barrier.

news

Innovative brain model provides patient-specific Alzheimer’s insights

3 September 2021 | By Anna Begley (Drug Target Review)

Researchers have turned human stem cells into brain cells to create a new model that can predict cognitive decline rate on an individualised level.

news

New screening method identifies COVID-19 protein inhibitor

3 September 2021 | By Anna Begley (Drug Target Review)

Researchers use fast and cost-effective technology to identify the viral protein inhibitor Mpro as a potential drug against COVID-19.

news

IAIPs shown to reduce ischemic stroke damage in pre-clinical study

2 September 2021 | By Anna Begley (Drug Target Review)

Inter-alpha inhibitor proteins (IAIP) demonstrated efficiency in reducing damage from an ischemic stroke, reveals pre-clinical study.

news

Controlling HSP27 “switch” could be key to sepsis therapeutics

1 September 2021 | By Anna Begley (Drug Target Review)

Study reveals that the HSP27 protein plays a role in regulating blood vessel leakage, providing new targets for drugs against sepsis.

news

DNA mechanism discovery may open up Huntington’s disease therapies

1 September 2021 | By Anna Begley (Drug Target Review)

Scientists unveiled how a DNA repair protein may prevent Huntington’s disease, presenting a new target in future therapies.

news

Novel model developed to resemble aberrant IPF lung epithelium

31 August 2021 | By Anna Begley (Drug Target Review)

A new model that closely resembles aged lung epithelium in idiopathic pulmonary fibrosis has been developed, possibly leading to treatments.

news

Detergent-like APOL3 protein shown to kill bacteria in human cells

27 August 2021 | By Anna Begley (Drug Target Review)

Researchers have revealed that the protein APOL3 acts as a detergent in human cells, potentially leading to new antibacterial treatments.

news

Spike gene mutants could be used as novel COVID-19 vaccine

27 August 2021 | By Anna Begley (Drug Target Review)

SARS-CoV-2 Spike gene mutants may be developed into immunogens for new vaccines against COVID-19, a study in hamsters has shown.

Illustration of blood clot with man holding chest in the background

news

Scientists discover new clue for platelet activation to target thrombosis

23 August 2021 | By Anna Begley (Drug Target Review)

Researchers have revealed a novel mechanism for platelet activation, suggesting a potential target for antithrombotic therapy.

article

Getting “under the skin” of frontotemporal dementia

23 August 2021 | By Anna Begley (Drug Target Review)

Researchers at the University of East Finland have been using skin cells to investigate pathological hallmarks in frontotemporal dementia patients.

news

Researchers discover glycan “gateway” that enables COVID-19 infection

20 August 2021 | By Anna Begley (Drug Target Review)

A supercomputing method has revealed details of glycan “gates” on the SARS-CoV-2 Spike protein that open to allow virus entry and infection.

news

New study discovers how Parkinson’s-linked protein attacks mitochondria

19 August 2021 | By Anna Begley (Drug Target Review)

Researchers have used fruit fly larvae to explore how alpha-synuclein impacts the mitochondria, advancing the study of Parkinson’s disease.

news

CureVac and GSK COVID-19 vaccine shows promise in pre-clinical study

17 August 2021 | By Anna Begley (Drug Target Review)

CureVac and GSK's second-generation mRNA COVID-19 vaccine candidate, CV2CoV, demonstrated improved immune response in a pre-clinical study.

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Protein