Protein

Bacterial proteins show promise for a gonorrhoea vaccine

20 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a pair of bacterial proteins that show promise as the basis for a gonorrhoea vaccine...

Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells

18 September 2017 | By Kim Luu (IntelliCyt Corporation), Robbie Narang (IntelliCyt Corporation), Zhaoping Liu (IntelliCyt Corporation)

In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...

New genetic cause discovered for photosensitive blood disorder

15 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have uncovered a new genetic cause for erythropoietic protoporphyria...

Application note: KingFisher Presto sample purification system

13 September 2017 | By Thermo Fisher Scientfic

In this application note Thermo Fisher Scientific compare data from the KingFisher Flex and KingFisher Presto instruments. Our results clearly indicate that the instruments produce equivalent yields and quality of extracted products. DNA extraction from human whole blood is shown as an example...

Cell surface protein may offer target in treating childhood cancers

12 September 2017 | By Dr Zara Kassam (Drug Target Review)

Immunotherapy drug candidate could be potent weapon against neuroblastoma and other paediatric malignancies...

Application note: Characterising chemokine receptor inhibitors with Alpha SureFire Ultra assays

12 September 2017 | By Daniel Cardillo, Jeanine Hinterneder, Matthew Marunde, Vincent Dupriez

In this application note, PerkinElmer discuss how their ValiScreen CXCR2 GPCR cell line (#ES-145-C) was utilised to examine the downstream effects of chemokine receptor modulation using multiple blocking antibodies and a small molecule...

QIAGEN N.V.

New marker could refine the process of producing hPSC-derived insulin cells

1 August 2017 | By Sarah Wills (Drug Target Review)

Scientists at the University of Copenhagen have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle to purify the cells whose fate is to become cells of the pancreas - including insulin producing cells.

Novel perspectives on anti-amyloid treatment for the prevention of Alzheimer’s

27 July 2017 | By Sarah Wills (Drug Target Review)

A collaboration between Prof Lucía Chávez-Gutiérrez and Prof Bart De Strooper of VIB-KU Leuven has revealed the molecular basis of the hereditary form of Alzheimer’s disease that strikes early in life.

Scientists uncover the structure of tau filaments from Alzheimer’s disease

6 July 2017 | By Drug Target Review

Researchers at the MRC Laboratory of Molecular Biology (LMB) have, for the first time, revealed the atomic structures of one of the two types of the abnormal filaments which lead to Alzheimer's disease.

Discovery improves understanding of cellular ageing and cancer development

5 July 2017 | By Niamh Marriott (Drug Target Review)

A team of researchers has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, key players involved in cellular ageing.

Review: Protein misfolding in neurodegenerative diseases

21 June 2017 | By Charles River Laboratories

Peer-reviewed publication on new strategies to target misfolded protein aggregates at various steps of protein production and processing...

Drug developed for arthritis could be first to stop heart valve calcification

16 June 2017 | By Niamh Marriott (Drug Target Review)

The first drug to treat calcification of heart valves may be one originally designed for rheumatoid arthritis.

Molecular Devices launches ImageXpress Nano System and CellReporterXpress Software

15 June 2017 | By Molecular Devices

ImageXpress Nano System makes automated imaging accessible for every lab conducting cellular imaging research...

Balance and movement improved in animal model of Parkinson’s disease

12 June 2017 | By Niamh Marriott (Drug Target Review)

Researchers have developed a molecular compound that improves balance and coordination in mice with early stage Parkinson's disease.