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Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
In this application note, PerkinElmer demonstrate the utility of an AlphaLISA assay for screening biotherapeutic antibodies and compounds that block binding of human PD-1 and PD-L1.
Drug discovery from concept to drug candidate has become a collective effort where multi-disciplinary project teams from CROs work with drug companies and academia to deliver clinical candidates, overcoming multi-factorial research obstacles along the way.
Declining R&D productivity is a key challenge in the pharmaceutical industry today.
In this In-Depth Focus on Screening, we look at clinically-oriented phenotypic screening and explore how 3-D bioprinted tissues can be used as disease-in-a-dish models for drug screening.
More than 90% of drugs that enter clinical evaluation fail to reach approval because of lack of efficacy or unexpected toxicity. This failure rate is in large part due to the use of overly simplistic in-vitro cell-based assays and animal models with limited predictive value...
Understanding the cancer cell phenotype is central to both cancer diagnosis and treatment. Discrete molecular signatures among cancer phenotypes underpin patient stratification, while rapid methods for detailed phenotyping in the clinic (via liquid biopsies and tumour imaging) enable the delivery of personalised, effective precision medicines to the cancer patient...
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
Scientists may have found possible targets for therapeutic interventions in the fight against Lou Gehrig’s disease.
Scientists have shown that it is possible to incorporate DNA analysis into antenatal screening for three serious chromosome disorders including Down's syndrome...
Improved methods validate the use of blood samples for studying patients' cancer genomes
Non-invasive diagnostic tool measures circulating microRNAs to predict ovarian cancer with specificity...
Screening for tumour cells in the fallopian tubes may help detect the cancer years before it develops further...
Cell confluency is a key parameter for all cell biologists as it is the beginning of all other cell culture experiment such as transfection, cell-based assays and cell culture quality control...
Scientists have identified five targets that reduce the parasite's ability to invade red blood cells...
6 October 2017 | By DiscoverX Corporation
In this webinar, we discussed how two qualification studies on KILR CD16 Effector Cells demonstrated accuracy and precision in different assays formats.
