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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
List view / Grid view
Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
news
Protein associated with ALS points to possible targets for therapeutic intervention
Scientists may have found possible targets for therapeutic interventions in the fight against Lou Gehrig’s disease.
news
DNA analysis incorporated into antenatal screening to test for chromosome disorders
Scientists have shown that it is possible to incorporate DNA analysis into antenatal screening for three serious chromosome disorders including Down's syndrome...
news
New techniques give blood biopsies greater promise
Improved methods validate the use of blood samples for studying patients' cancer genomes
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Blood test developed to diagnose ovarian cancer
Non-invasive diagnostic tool measures circulating microRNAs to predict ovarian cancer with specificity...
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TP53 gene mutations may help catch ovarian cancer
Screening for tumour cells in the fallopian tubes may help detect the cancer years before it develops further...
whitepaper
Whitepaper: Automatic calculation of HeLa cell culture confluency
Cell confluency is a key parameter for all cell biologists as it is the beginning of all other cell culture experiment such as transfection, cell-based assays and cell culture quality control...
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Five new malaria targets that could lead to an effective vaccine
Scientists have identified five targets that reduce the parasite's ability to invade red blood cells...
webinar
Implementing ADCC assays in QC: When donor variability isn’t an option
6 October 2017 | By DiscoverX Corporation
In this webinar, we discussed how two qualification studies on KILR CD16 Effector Cells demonstrated accuracy and precision in different assays formats.
webinar
Advancing the discovery of immunotherapeutics with large scale multiplexed experiments
27 September 2017 | By IntelliCyt Corporation
In this webinar, Belen Ybarrondo, Ph.D and Thomas Duensing, Ph.D discuss the challenges faced with antibody screening and how the iQue Screener can give an evaluation of cell killing mechanism, screening for immune checkpoint inhibitors and more...
whitepaper
Application note: Multiplexed detection of mouse cytokines using QBeads and the iQue Screener
This application note illustrates the value of multiplexing, rapid sampling, and assay miniaturisation using QBeads on the iQue Screener...
webinar
Evaluating immunotherapeutic approaches with large scale functional assays for immuno-oncology
22 September 2017 | By IntelliCyt Corporation
In this webinar, Belen Ybarrondo, Ph.D and Thomas Duensing, Ph.D discuss the need for robust high content tools for current immunotherapeutic approaches, and how IntelliCyt's iQue Screener PLUS can give functional efficacy of immuno-oncology therapies...
whitepaper
Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
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Assay development for image-based high-content screening
Image-based high-content screening (HCS) is a high-throughput screening (HTS) technology that combines automated fluorescence microscopy from microtiter plates with digital image analysis. This effectively allows phenotypic screening with sufficient throughput to interrogate large compound libraries...
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New genetic cause discovered for photosensitive blood disorder
Researchers have uncovered a new genetic cause for erythropoietic protoporphyria...
