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Therapeutics

Drug Target Review Synthetic Biology ebook 2021

22 September 2021 | By Drug Target Review

In this ebook, discover why CRISPR can aid the development of new drugs via loss-of-function screens and how the field of synthetic biology is likely to evolve within the context of health.

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Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

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Eczema may stem from poorly regulated sex hormones, study finds

20 September 2021 | By Anna Begley (Drug Target Review)

A breaking discovery has revealed the gene HSD3B1 that regulates the production of sex hormones is linked to atopic dermatitis (AD).

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Controlling PTEN gene could combat paediatric rhabdomyosarcoma

20 September 2021 | By Anna Begley (Drug Target Review)

The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.

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Scientists create organoid biobank to study SARS-CoV-2 genes

20 September 2021 | By Anna Begley (Drug Target Review)

Researchers have established an organoid biobank to search for genes that are essential for the spreading of SARS-CoV-2 infection.

Staphylococcus Aureus grown in petri dish

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Ex vivo stem cell treatment a promising therapy against MRSA

17 September 2021 | By Anna Begley (Drug Target Review)

A new ex vivo model treated animal wounds with mesenchymal stromal cells (MSCs) and reduced MRSA infection, expanding therapeutic options for humans.

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Scientists reveal that glioblastoma shows dependency on biotin distribution

15 September 2021 | By Anna Begley (Drug Target Review)

Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.

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Gut microbiome linked to rheumatoid arthritis prognosis

15 September 2021 | By Anna Begley (Drug Target Review)

New genomic study reveals that the microbiome could predict rheumatoid arthritis prognosis, potentially advancing treatments.

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Gene therapy for Morquio A disease successful in rat model

14 September 2021 | By Anna Begley (Drug Target Review)

A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.

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Scientists create cellular blueprint of multiple sclerosis lesions

13 September 2021 | By Anna Begley (Drug Target Review)

An NIH team have built a cellular map of chronic multiple sclerosis (MS) lesions to identify cells that drive inflammation and potential therapies.

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STING-activating drugs could customise cancer treatments

9 September 2021 | By Anna Begley (Drug Target Review)

An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.

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Stem-like T cells could improve immunotherapy treatments

7 September 2021 | By Anna Begley (Drug Target Review)

Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.

Woman cutting DNA molecules, indicating CRISPR

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Researchers engineer “mini” CRISPR genome editing system

7 September 2021 | By Anna Begley (Drug Target Review)

Stanford researchers have developed a multi-purpose “mini” CRISPR system, called CasMINI, that may be easier to deliver into human cells.

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Scientists discover mechanism behind cardiac hypertrophy

6 September 2021 | By Anna Begley (Drug Target Review)

New research has uncovered a mechanism underlying cardiac hypertrophy in mice, spurring novel avenues for potential treatments.

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RN7SL1 RNA shown to activate T cells to fight against cancer

6 September 2021 | By Anna Begley (Drug Target Review)

A new study found that the RNA RN7SL1 can activate T cells to seek out cancer cells, potentially improving cellular treatments.

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