Product hub: Why automation is outpacing traditional methods for single-cell cloning
Posted: 30 March 2023 | Sartorius | No comments yet
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Genetic modification of mammalian cells has a breadth of use in biotherapeutics development and basic research applications. An important step early on is the isolation of clones with the desired mutation prior to downstream analysis. While fluorescence-activated cell sorting (FACS) and limiting dilution have traditionally been the methods of choice, many are turning to automated, image-based solutions.
Read the following article where we cover:
- The importance of monoclonality
- What is limiting dilution?
- Additional requirements in cell line development
- Image-based systems for single cell isolation.
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Biotherapeutics, Cell Line Development, CRISPR, Genome Editing, Imaging, Lab Automation, Targets, Technology