Despite the promise of gene therapies, significant challenges have emerged in the field. Dr Carsten Brunn discusses the current obstacles and opportunities when developing gene therapies.
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A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.
A team has created a biosynthetic pathway for E. coli that allows the bacteria to produce a common arthritis drug.
A molecule called TPPU has been shown to inhibit an enzyme that plays a key role in inflammation, successfully treating arthritis in mice.
Researchers observed that deleting the IRE1-alpha gene caused beta cells to de-differentiate and then re-differentiate in mice, preventing immune system auto-activation.
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
Scientists have discovered that itaconate - a molecule derived from glucose - acts as a powerful off-switch for macrophages...
A research team has discovered the process - and filmed the actual moment - that can change the body’s response to a dying cell.
Scientists have discovered a molecule that enhances cartilage regeneration and decreases inflammation.
Researchers have found a pattern of genes which is characteristic of osteoarthritis and may be a step towards better treatments for this condition.
The first drug to treat calcification of heart valves may be one originally designed for rheumatoid arthritis.