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Unexpected neuronal molecule makes prostate cancer more aggressive
US researchers discover a potential therapeutic avenue through the molecule NgR2, against an aggressive form of prostate cancer.
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Prostate cancer
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New prostate cancer subtype may illuminate treatment strategy
Researchers have identified a previously unrecognised form of hormone therapy-resistant prostate cancer.
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Novel technique to rapidly find prostate cancer drugs
A new screening assay could be used to identify new drugs to treat resistant forms of prostate cancer.
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Prostate cancer organoids pave way towards precision oncology
Scientists develop organoid models of neuroendocrine prostate cancer to study EZH2 inhibitors and reveal a potential new target.
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Researchers identify RNA molecule that suppresses prostate tumours
Scientists discover a long noncoding RNA, termed NXTAR, and a small molecule drug that could be used to treat prostate cancer.
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High-intensity focused ultrasound therapy moves closer to the clinic
Researchers are investigating how high-intensity focused ultrasound (HIFU) can work on a cellular level to treat a range of cancers.
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Computational method developed to map chromosome folding in 3D
Researchers created their new method to analyse chromosomes in 3D, revealing how misconfigurations play a role in cancer.
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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
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Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
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Could metabo-oncology be the treatment modality of the future?
Jim Shanahan from SynDevRx explains why metabo-oncology treatment modalities could be the answer to a rise in metabolic disorders and cancers.
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AI advancing drug discovery: the future is multi-cellular studies
Drs Sam Cooper and Michael Briskin of Phenomic AI, discuss how artificial intelligence (AI) is enabling them to target multi-cellular interactions, such as those in the tumour stroma, for drug development.
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Novel prostate cancer resistance mechanism could be a promising target
By inhibiting the activity of microRNA-194 (miR-194), scientists prevented prostate cancer cells from developing treatment resistance in vitro.
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Cancer-killing virus could improve precision medicine
A new cancer-killing virus called CF33 has shown success in pre-clinical trials, helping the immune system to eradicate tumours.
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CRISPR used to eliminate cancers caused by fusion genes
Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.
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High-throughput screening as a method for discovering new drugs
High-throughput screening is a common method of identifying lead compounds for drug development. The most common targets are enzymes – catalytic proteins that perform chemical reactions in the cell. In this article, Matthew Lloyd discusses the opportunities and challenges associated with this approach.